Browsing Fakultät für Chemie (inkl. GAUSS) by Advisor & Referee "Diederichsen, Ulf Prof. Dr."
Now showing items 1-20 of 102
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Probing SNARE-Induced Membrane Fusion Using Peptidic Model Fusogens
(2022-11-10)In this thesis, SNARE analogues with artificial recognition units made of either coiled-coil sequences or peptide nucleic acid (PNA) oligomers were synthesized. By applying FRET-based liposome fusion assays, the fusogenic ... -
Synthesis of Orotidine-5'-monophosphate modifications for the study of the catalytic activity of the enzyme Orotidine-5'-monophosphate decarboxylase
(2022-01-27)In this thesis, the synthesis of OMPD substrate analogs was investigated to further elucidate the mechanism of the OMPD. As inhibiting molecules, 6-thioamido UMP, OMP methyl ester, reduced OMP, and nonpolar substituted ... -
Synthesis of β-Peptides for the Organization as Helix Bundles in Lipid Membranes
(2021-12-03)In this work, syntheses and analyses of transmembrane β-peptides were performed. On the one hand, a novel β-peptidic molecular ruler was designed which enables the measurement of near-membrane ion concentrations. On the ... -
Synthesis of new, rigid and conformation stabilizing spin labels for analysis of the orientation of transmembrane domains
(2021-11-15)Lipid-peptide interactions are involved in many essential processes of living organisms, such as cell fusion or transport processes and are therefore, in the center of research interest. One efficient technique to analyze ... -
Prebiotic Synthesis of Inorganic Pyrophosphate (PPi) Driven by a Geochemical Redox Reaction
(2021-10-21)In all extant organisms adenosine triphosphate (ATP) is the energy carrier and transmitter of free energy from exergonic to endergonic processes. Since ATP is a complex molecule, it was unlikely available on prebiotic ... -
Investigation of Peptidic Templates for Bioorthogonal Ligations
(2021-08-16)One of the biggest challenges for biochemical researchers in the postgenomic era remains the elucidation of structure-activity relationships in proteins. While many proteins can be routinely produced by recombinant protein ... -
Design and synthesis of small organic molecules to stabilize ALS-associated SOD1 mutants
(2021-06-25)Amyotrophic Lateral Sclerosis is a globally occurring neurodegenerative disease with serious implications for the patient’s life as well as imposing a heavy economic burden both on the affected individuals and society. Due ... -
Synthesis of Modified Biomolecules to Investigate Neuronal Processes
(2021-04-30)Action potentials are an essential process for signal transmission in excitable cells. At chemical synapses, the action potential triggers the release of neurotransmitters from synaptic vesicles to transmit the signal to ... -
S-Substituted Dibenzothiophenium Triflates: Synthesis, Structure and Reactivity
(2021-04-23)The content of this thesis focused on the general syntheses and applications S-substituted alkynyl-, alkenyl- and aryldibenzothiophenium triflates. Addition reactions have been performed from S-alkynyldibenzothiophenium ... -
Investigation of the Linker Region of Coiled Coil SNARE-Analoga and Membrane Composition on Vesicle Fusion
(2021-03-09)SNARE (soluble N-ethylmaleimide-sensitive-factor attachment receptor) proteins play a major role in membrane fusion processes in many organisms. As these proteins form a sophisticated tetrameric coiled coil complex, many ... -
Design and synthesis of multifunctional ligands to study and prevent aggregation processes in Amyotrophic Lateral Sclerosis proteins
(2021-02-22)Amyotrophic lateral sclerosis (ALS) is an incurable lethal disease that affects motor neurons and its heterogeneity is reflected in various mutations among the sporadic ALS (sALS) and familial ALS (fALS) disease types. ... -
Modification of transmembrane peptides to probe SNARE-induced membrane fusion and cross-presentation of membrane-buried epitopes
(2021-02-19)Membrane proteins play an important role in cellular function as receptors, transporters, anchors, and catalysts. Despite constituting 20-30% of the human proteome only 3 % of all characterized proteins are membrane proteins ... -
Oligomer modulator anle138b and related compounds in neurodegeneration and beyond
(2020-12-10)Neurodegenerative diseases including Alzheimer’s disease, Parkinson’s disease, Creutzfeldt-Jakob disease are characterized by a progressive deterioration of brain function as a result of a gradual loss of nerve cells. Due ... -
Synthesis of rare nucleobases and artificial nucleotides for investigation of catalytic enzyme activity
(2019-10-25)Enzymes are involved in replication, transcription and translation of DNA, as well as the synthesis of nucleobases. The roles and mechanisms for many of these enzymes stay broadly unknown until today. The herein presented ... -
Self-Organization of β-Peptide Nucleic Acid Helices for Membrane Scaffolding
(2019-08-06)In a vast number of cellular processes interactions between membranes and proteins are essential, resulting in the lipid bilayer being interspersed immensely with proteins. Apart from catalytic or signaling functions, a ... -
Synthesis, characterisation and sensor-functionalisation of transmembrane β-peptides
(2019-07-31)Membrane proteins represent an important class of proteins as they are encoded in up to 30 % of the open reading frame. More than 50 % of currently available drugs target membrane proteins, emphasising the importance of ... -
Synthesis and Characterization of Polydentate C3 Symmetric Ligand Systems in Metal Coordination
(2019-06-03)Tripodal ligand systems are of key interest in the synthesis of new and promising metal complexes since their tridentate coordination sphere can be used to generate a multitude of different bonding motifs with a suitable ... -
Beta-Peptide Helices As Transmembrane Domains: Aggregation, Recognition and Lipid-Peptide Interaction
(2019-01-25)Plasma membranes are considered as the primary regulatory unit essential for efficient functioning of a cell. These membranes separate the inner part of the cell from the extracellular world as well as acts as a barrier ... -
Influence of point mutations on the electrophysiological properties of a bacterial porin and its interaction with a β-lactam antibiotic
(2018-09-19)The high rate of complications and mortality in hospitals due to multidrug resistances (MDR) of gram-negative bacteria demonstrates the urgency to understand the underlying mecha-nisms. One common cause of MDR are mutations ... -
Synthesis of Rigid Spin Labels for the Investigation of Transmembrane Peptides by EPR Spectroscopy
(2018-04-27)Transmembrane model peptides enable the investigation of complex protein-lipid interactions since the specific structure of proteins is influenced by the lipid environment. Herein, the synthesis of nitroxide spin labels ...