Browsing Fakultät für Chemie (inkl. GAUSS) by Advisor & Referee "Janshoff, Andreas Prof. Dr."
Now showing items 1-20 of 21
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Development of Bone Adhesive Materials based on Collagen-mimetic Peptides and Carbene-mediated Diazirine Crosslinkers
(2024-08-22)Traditional mechanical fixation methods such as screws, support plates, staples, and sutures remain predominant in treating bone trauma. However, these methods can cause localized tissue damage, leading to infection and ... -
Testing tube model predictions on semi-flexible polymer networks
(2023-11-13)The mechanical properties of simple entangled actin filament networks in eukaryotes are well understood as they are predictable with model systems. The high complexity of cellular actin structures like the cell cortex for ... -
Epithelial Cells under Mechanical Strain: an Investigation
(2022-06-29)Cells are the minimal living unit of the body. Each cell plays a vital role that must withstand various stresses, from chemical environments to mechanical strain and temperature variations. One of these vital cell types ... -
Detecting the Undetectable: Functional Protein Motions in the Hidden Timescale Window Revealed by NMR Relaxation Measurements
(2022-05-19)About 50 years ago, even before NMR was ready to determine structure of proteins, it could unveil a surprising motion in aromatic side-chain (Wuthrich & Wagner, 1975) from 1D 1H spectra. With decades of development, NMR ... -
Precise Nanoengineering of Polymer Functionalized Nanomaterials with Silica as Coating and Templating Tools
(2022-05-10)The construction of a well-defined hybrid nanostructure becomes possible if functional polymer meets inorganic nanomaterials in a well-designed way. To fully control the structure of the nanohybrid and create the synergy ... -
Herstellung und Charakterisierung von Polymernetzwerken im Kontext der präparativen Membranchromatographie
(2022-03-04)Preparative chromatography is an essential part in the industrial purification of biopharmaceuticals and thus allows the targeted therapy of severe diseases like cancer, multiple sclerosis or rheumatism. It enables the ... -
In and through the membrane by solid-state NMR: investigations of the human voltage-dependent anion channel 1 and Nup98-derived FG-domains
(2022-02-22)Magic-angle-spinning NMR spectroscopy is a powerful tool for the investigation of protein structure, dynamics and interactions at atomic resolution. We have applied this technique to investigate two widely different systems: ... -
Fluoreszente Sonden mit gesteigerter Signalintensität für die Lebendzell-Mikroskopie
(2021-09-02)In the past decades key findings in light microscopy has extended the possibilities of optical imaging methods. Imaging of living cells with a detailed visualization of proteins, structures and organelles has become one ... -
Active Matter in Confined Geometries - Biophysics of Artificial Minimal Cortices
(2020-12-18)Essential physiological processes, such as cell motility, adhesion, growth and differentiation are determined by the ability of cells to modify their mechanical properties. Consequently, both the vitality as well as ... -
Binary Planet–Satellite Nanostructure Using RAFT Polymer
(2020-08-06)This thesis provides a series of strategies to fabricate hierarchically arranged nanohybrids from distinct nanoparticles using polymer linkers. Benefit from the controlled reversible-deactivation radical polymerization ... -
Low-Voltage Electrowetting on Dielectrics Integrated and Investigated with Electrical Impedance Spectroscopy (LV-EWOD-EIS)
(2018-10-18)Electrowetting on dielectrics (EWOD) is an electrically controllable wetting effect, that has been applied in diverse fields including optics, displays and lab on a chip systems. However, the further development of EWOD ... -
Anwendungsbezogene Weiterentwicklung der abbildenden Ellipsometrie
(2017-10-10)Since the work of Geim of graphene as the first 2D material, application and rese- arch of 2D materials is the main booming branch this decade. Overall the imaging techniques like RAMAN Imaging, AFM and optical microscopy ... -
Synthesis of fluorescent toxin and nucleotide derivatives to specifically address membrane proteins
(2015-07-15)Within this project, new tools for in vivo/in vitro labelling were developed and investigated, which may be utilized in the future to elucidate structures, localisation and distinct processes of biomolecules in their native ... -
Optical Fusion Assay Based on Membrane-Coated Beads in a 2D Assembly
(2014-04-25)A novel assay of membrane fusion is established based on membrane-coated beads in a 2D assembly. This assay allows identifying the different stages of the fusion process. Membrane fusion driven by heterodimeric coiled coil ... -
Development of a Biomembrane Sensor Based on Reflectometry
(2013-09-13)Membrane proteins play central roles in many significant cellular processes such as signal transduction, cell adhesion and immune recognition reactions. As a result, they gained substantial pharmacological significance, ... -
Modell der Bildung und Stabilität von Adhäsionsclustern in biologischen Membranen
(2013-08-22)Cellular adhesion is pivotal in cell development, tissue formation and motility. The orchestration of cellular adhesion is an intricate process that involves a multitude of specialized proteins but at the same time follows ... -
A Force Spectroscopy Setup to Mimic Cellular Interaction Processes
(2013-06-21)The main objective of this thesis was to establish a biophysical model system that permits to quantify forces involved in cell-cell contacts and cell-substrate-adhesion in a native-like fashion. For this purpose, colloidal ... -
Membrane mechanics governs cell mechanics in epithelial cell: how surface area regulation ensures tension homeostasis
(2013-04-04)The plasma membrane tension in eukaryotic cells is supposed to be a major regulator of many cellular processes that involve changes in membrane area and membrane deformation including cell migration, mitosis, endo -and ... -
Mechanik und Dynamik biologischer Modellsysteme am Beispiel aktingefüllter Vesikel und synchroner Zellmigration von Dictyostelium discoideum
(2013-02-06)This thesis analyzes the dynamics of cell contacts of synchronic cells and the mechanical characteristics of the plasma membrane on the basis of two different model systems. The first model system consisting of the amoebae ... -
Lateral Organization and Thermodynamics of Coiled-coil Lipopeptides - Implications for Docking and Fusion Efficiency
(2013-01-24)Specific cellular membrane interaction is a crucial point in nature as it facilitates key processes like cell-cell communication or membrane fusion. The latter one is highly controlled frequently mediated by the superfamily ...