Browsing Fakultät für Chemie (inkl. GAUSS) by Advisor & Referee "Koszinowski, Konrad Prof. Dr."
Now showing items 1-20 of 57
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Enabling Novel Fluoroalkylation via Sulfonium Salt Transfer Reagents
(2024-08-26)Over the past four decades, sulfonium salt-based transfer reagents have evolved into widely recognized tools for fluoroalkylation in the synthetic chemistry community. These reagents have enabled the incorporation of various ... -
Selectivity controlling factors in the reductive elimination of coinage metal complexes
(2024-07-12)In this thesis, reductive elimination reactions and their selectivity-determining factors were investigated using ESI and tandem-MS. To this matter, square-planar coordinated coinage- metalate complexes bearing ... -
Synthesis of Novel Sulfur(VI) Reagents and the Regioselective Functionalization of Helicenes by Hypervalent Reagents
(2024-06-28)The synthesis of novel sulfur(VI) reagents was investigated. For this purpose different sulfurane oxides were synthesized. The functionalization of these compounds was unsuccessful due to decomposition or inertness of the ... -
meta-C−H Functionalization and Sustainable Electro- /Photoelectrocatalytic C−H/Si−H/Ge−H Activation
(2024-06-18)C−H activation provides a crucial new tool for the construction of C−C bonds in organic chemical synthesis, especially for agrochemistry, the pharmaceutical industry, and materials science, using a large number of existing ... -
Palladium- and Ruthenium-Catalyzed C(sp2)–H and C(sp3)–H Arylations
(2024-06-05)Catalysis is arguably the most impactful area of chemistry for society today, driven by the urgent need for highly efficient and environmentally benign reactions. C−H activation, which allows for the direct introduction ... -
Electrochemical C–H Activation by Ruthenium and Palladium Catalysis
(2024-04-19)The emergence of direct functionalizations of C−H bonds offers efficient alternatives to traditional cross-coupling reactions, thereby saving time and costs. However, oxidative C−H activation often depends on stoichiometric ... -
Sustainable Ruthenium- and Rhodium-Catalyzed C−H Activations with Photochemistry and Electrochemistry
(2024-03-18)Cross-coupling chemistry stands out as a fundamental tool in synthetic organic chemistry for forging C‒C and C‒Het bonds. However, the necessity for substrate prefunctionalization imposes significant sustainability challenges ... -
Weiterentwicklung diffusionsspektroskopischer NMR-Methoden für metallorganische Schlüsselverbindungen
(2023-10-02)This work has extended the development and application of NMR diffusion spectroscopic techniques for the determination of the molecular weight of compounds in solution. In the process, methylcyclohexane-d14 was added to ... -
Barriers of Protonation Reactions of Organometallics
(2023-09-20)Protonation reactions are entirely understood for simple organic and inorganic molecules and there are elaborated concepts to describe such acid-base reactions in both the solution and gas phase. For organometallic species, ... -
Diversity-Oriented Assembly of C-Glycosides via Late-Stage C−H Glycosylation
(2023-08-29)C-glycosides are widely distributed structural motifs found in natural products and commercially available drug molecules. Due to the stability of glycosidic C-C bonds against chemical and enzymatic hydrolysis, only ... -
Bioinspired dioxygen activation with copper complexes supported by Bis(oxazoline) and Bis(benzimidazole) ligands
(2023-06-20)Many synthetic complexes modeling the oxy form of the tyrosinase have been developed and have shown a preference for either the side-on peroxodicopper(II) (P) or the bis(-oxo)dicopper(III) (O) core depending on the ... -
Sustainable Methods in C–H Functionalizations
(2023-05-30)Cross-coupling chemistry has matured in an attractive tool in synthetic organic chemistry to realized efficient formation of C‒C and C‒Het bonds. However, these transformations are also associated with certain drawbacks, ... -
Electrospray-Ionization Mass Spectrometry for the Analysis and Quantification of Carbanions
(2023-03-23)The suitability of ESI-MS for the analysis of carbanions was investigated, including the effects of their basicity, concentration and the experimental conditions. This was followed by exemplary applications, such as live ... -
Mikroskopische Reaktivität Metallorganischer Spezies
(2023-03-15)In oder to better understand cross-coupling reactions, the oxidative addition between organo halides and organometallates based on iron, cobalt and copper was investigated by using ion-molecule reactions in the gas phase. ... -
C–H Activation via Iridium and Rhodium Electrocatalysis and Undirected Electrochemical Fluorination
(2022-06-24)In past decades, transition metal-catalyzed C–H activation has emerged as an increasingly viable toolbox for the step- and atom economic formation of C–C and C–Het bonds. However, oxidative C–H transformations heavily rely ... -
Towards a total synthesis of bazzanin K
(2022-05-31)Bazzanin K is a natural product from the group of macrocyclic bis-bibenzyls which was isolated from the liverwort bazzania trilobata. This work is dedicated towards the development of a synthetic strategy with bazzanin K ... -
Metal-induced aggregation of ß-peptides on membrane surfaces
(2022-04-05)According to the liquid mosaic model of Singer and Nicolson, the cell membrane defines the boundaries of a cell to the inside and outside and describes a twodimensional lipid bilayer. Integrated into this lipid bilayer ... -
Bioinspired Iron-Carbene Models of Heme and Non-Heme Enzymes: Electronic Structure and HAA Reactivity
(2022-03-15)The fast depletion of non-renewable energy sources requires modern chemists to develop new industrial processes that are more efficient and environmentally sustainable. In this framework, the functionalization (e.g. ... -
Merging Electrosynthesis with 3d Transition Metal-Catalyzed C–H Transformations
(2021-07-12)In recent years, oxidative C–H transformations have emerged as increasingly powerful tools in molecular syntheses. However, despite great progress towards more atom and step economic synthetic methods, oxidative couplings ... -
Resource-Economical C–H Activation for Late-Stage Functionalization
(2021-07-07)Organic synthesis has traditionally relied on step-, time- and resource-intensive strategies, namely the functional group interconversion and, more recently, on cross-coupling reactions. These approaches have enabled the ...