Browsing Fakultät für Chemie (inkl. GAUSS) by Advisor & Referee "Laatsch, Hartmut Prof. Dr."
Now showing items 1-20 of 38
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Zugang zu Agrar- & Pharmawirkstoffen durch organische Synthese
(2015-07-30)This thesis contains the design of new spinosyn analogues via two subsequent heck reactions as well as the modification of a beta-selective glycoslylation method and the synthesis of six new potential Hsp47 inhibitors based ... -
Crystal Structures of a Bacterial Isocitrate Dehydrogenase and the Human Sulfamidase
(2015-01-09)In an X-ray crystallographic experiment, intensities and directions of X-rays scattered by electrons in a crystal are measured. However, the relative phase information in the interference pattern is lost. If we knew the ... -
Isolation, Purification and Structure Elucidation of New Secondary Metabolites from Terrestrial, Marine, and Ruminal Microorganisms
(2012-12-19)The search for microorganisms useful in agriculture, agroalimentary and pharmaceu-tical industries requires the exploration also of ecological niches. Thus, within this background, the rumen (one of the four stomach parts ... -
Asymmetrische Allylierung von prochiralen Ketonen und deren Anwendung in der Synthese von Pinnatolid und Furopinnatin
(2012-07-30)Allylation reactions are one of the most frequently employed C–C bond formation reactions which are often used in the synthesis of natural compounds. There are many procedures known for asymmetric allylation of aldehydes ... -
Aufbau von Bausteinen zur Synthese von Spinosynanaloga
(2012-05-22)The Spinosyns A and D are the main metabolites of the Streptomyces species Saccharopolyspora spinosa. They show a high activity as well as a high selectivity against a huge number of insects that cause extensive damage ... -
Bandamycin as New Antifungal Agent and further Secondary Metabolites from Terrestrial and Marine Microorganisms
(2012-05-03)In this study, eight terrestrial and two marine bacteria, and four endophytic fungi have been investigated chemically and pharmacologically, out of which a total of fourty-eight secondary metabolites were isolated. ... -
Synthese und biologische Evaluierung neuartiger Acronycin-Duocarmycin-Hybride
(2012-02-17)A new hybrid comprising the structure of natural products acronycine and duocarmycin was synthesized and biologically evaluated. -
Synthese und biologische Evaluierung von fluorezenzmarkierten Duocarmycin-Analoga
(2012-02-16)The chemotherapy of malign tumours is severely restricted due to severe side effects of the available anticancer agents. A novel approach to overcome these limitations is the Antibody ... -
Indole Alkaloids as Potential Leads in Drug Discovery and Further Secondary Metabolites from Terrestrial and Marine Bacteria
(2012-01-04)Microorganisms take a large influence on ecological and symbiotic interactions in long-term relationships that are moderated by secondary metabolites with often-unique structure and biological ... -
Dehydrorabelomycin-1-O-α-L-rhamnopyranoside, Actinofuranone C and Further New Bioactive Secondary Metabolites from Terrestrial Streptomyces spp.
(2011-09-22)Natural products have been used to combat infectious diseases since ages. However, increased resistance to existing antibiotics and emergence of new diseases stimulated the development of ... -
Palladium(II)-katalysierte Domino-Reaktionen zur enantioselektiven Synthese von Confluentin, Daurichromen- und Rhododaurichromansäure Untersuchungen zur Synthese von Aglaroxin A
(2011-04-28)This thesis is about Palladium(II) catalysed Domino Reactions for the enantioselective Synthesis of Confluentin, Daurichromenic and Rhododaurichromanic acid. These substances were isolated ... -
Aqabamycins, Rare Nitro Maleimides and other Novel Metabolites from Microorganisms; Generation and Application of an HPLC-UV-ESI MS/MS Database
(2009-06-04)The battle to improve the quality of life by finding cures against diseases and to extend the life expectancy of mankind is still one of the priorities in natural products chemistry. Al-though ... -
Struktur und Biosynthese von Spirodionsäure und Kirromycin aus Streptomyces sp.
(2009-04-09)The first project is about the investigation of the biosynthesis of the novel microbial metabolite spirodionic acid and its absolute stereoconfiguration. Within the scope of these biosynthetic ... -
Nafisamycin, Cyclisation Product of a New Enediyne Precursor, Highly Cytotoxic Mansouramycins, Karamomycins Possessing a Novel Heterocyclic Skeleton and Further Unusual Secondary Metabolites from Terrestrial and Marine Bacteria.
(2009-03-19)The search for new medically active compounds to overcome the countless diseases is one of the most relevant objectives worldwide. Medicinal plants were used previously in the traditional ... -
Unusual Sesquiterpenes: Gorgonenes and Further Bioactive Secondary Metabolites Derived from Marine and Terrestrial Bacteria.
(2009-03-16)An increasing number of infectious diseases is still not curable as many organisms are showing antibiotic resistance which urges the development of new medicaments to combat them. Natural ... -
New and Bioactive Secondary Metabolites from Ma-rine and Terrestrial Bacteria: Ramthacin A, B, C, and Polyene Macrolides from Genetically Modified Bacteria
(2009-01-09)Natural products have provided the major sources of chemical diversity for phar-maceutical discoveries for many decades. For clinical application to treat human dis-eases in almost all ... -
Crystallographic studies on DNA in complex with antibiotics and effects of anisotropic scaling on structure solution
(2008-12-01)This work investigates the structure of complexes between DNA and antibiotics discussing the crystal structures of d(AACCGGTT)-trioxacarcin, d(CGTACG)-trioxacarcin and d(ACGTACGT)-echinomycin. ... -
Sekundärstoffe aus endophytischen Pilzen mariner Habitate und Abbaureaktionen an Simocyclinon D8
(2008-01-09)This thesis deals with the isolation, characterization und chemical derivatization of natural products. Most of the described metabolites show a high potential biological activity which is ... -
Zur Biosynthese des Borrelidins sowie Isolierung und Strukturaufklärung von Sekundärmetaboliten aus marinen und terrestrischen Mikroorganismen
(2007-11-06)The relevance of natural products in pharmacological research is now after a long period again gaining more and more attention. Different aspects of natural product research are covered by ... -
Untersuchungen zur Synthese von Yohimban- und Campthoteca-Alkaloiden durch Domino-Knoevenagel-Hetero-Diels-Alder-Reaktion
(2007-11-01)In this context, the domino reactions proved to be an excellent tool to access complex molecules from simple substrates in environmentally and economically sustainable way. This ...