Browsing Fakultät für Chemie (inkl. GAUSS) by Advisor & Referee "Tietze, Lutz Prof. Dr. Dr. h.c."
Now showing items 1-20 of 40
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Diversity-Oriented Assembly of C-Glycosides via Late-Stage C−H Glycosylation
(2023-08-29)C-glycosides are widely distributed structural motifs found in natural products and commercially available drug molecules. Due to the stability of glycosidic C-C bonds against chemical and enzymatic hydrolysis, only ... -
Sustainable Methods in C–H Functionalizations
(2023-05-30)Cross-coupling chemistry has matured in an attractive tool in synthetic organic chemistry to realized efficient formation of C‒C and C‒Het bonds. However, these transformations are also associated with certain drawbacks, ... -
Transition Metal- and Electro-Catalyzed C-H and B-H Activation for the Efficient Synthesis of Carborane Derivatives
(2023-01-12)The emergence and rapid development of transition metal-and electro-catalyzed C-H activation has proven to be a powerful tool in the assembly of complex molecular structures. in addition, the selective synthesis of carborane ... -
Resource-Economical C–H Activation for Late-Stage Functionalization
(2021-07-07)Organic synthesis has traditionally relied on step-, time- and resource-intensive strategies, namely the functional group interconversion and, more recently, on cross-coupling reactions. These approaches have enabled the ... -
Cobalt(III)- and Manganese(I)-Catalyzed C-H and C-C Activations
(2019-03-28)Metal-catalyzed C─H and C─C functionalizations have become an increasingly viable approach, which allows the direct formation of C─C and C─heteroatom bonds in an atom- and step-economical manner. However, the significant ... -
Untersuchungen zur enantioselektiven Totalsynthese von Parnafungin C
(2016-10-10)Within this thesis, two fragments of the natural product Parnafungin C, a highly functionalized chiral chromane with the correct absolute and relative configuration of all stereogenic centers as well as a biaryl system ... -
Domino-Reaktionen mit anti-Carbopalladierungen an Alkinen als Schlüsselschritt und Transformationen von Arylthiocyanaten mit Arinen
(2015-09-09)The work presents a formal anti-carbopalladation reaction of alkynes imbedded into a domino reaction for the synthesis of oligo cyclic structures. Therefore, intra- as well as intermolecular approaches were performed. ... -
Zugang zu Agrar- & Pharmawirkstoffen durch organische Synthese
(2015-07-30)This thesis contains the design of new spinosyn analogues via two subsequent heck reactions as well as the modification of a beta-selective glycoslylation method and the synthesis of six new potential Hsp47 inhibitors based ... -
Domino Reactions for the Syntheses of Chiral Chromanes ‒ Enantioselective Total Syntheses of (‒)-Diversonol, (‒)-Blennolide C, (‒)-Gonytolide C and Formal Synthesis of Siccanin
(2015-06-15)The general objective of this thesis is to demonstrate the synthetic utility of the domino concept in the complex setting of natural product synthesis. Key step is a palladium-catalyzed domino Wacker/carbonylation/methoxylation ... -
Untersuchungen zur Synthese fluoreszenzaktiver aromatischer Polyzyklen durch Palladium-katalysierte Domino-C‒H-Aktivierungen
(2014-11-18)Fluorescent dyes were synthesized via novel fourfold Palladium-catalyzed domino reactions consisting of a Sonogashira reaction, two carbopalladations and a C-H-activation in one domino process. -
Synthese und biologische Evaluation neuartiger Duocarmycin-Analoga für eine selektive Krebstherapie
(2013-06-07)To date most anticancer agents interact with the cell cycle and therefore traditionally damage only cells with high proliferation rates. The usually insufficient differentiation between normal and malignant cells results ... -
Synthese und biologische Evaluierung neuartiger Acronycin-Duocarmycin-Hybride
(2012-02-17)A new hybrid comprising the structure of natural products acronycine and duocarmycin was synthesized and biologically evaluated. -
Synthese und biologische Evaluierung von fluorezenzmarkierten Duocarmycin-Analoga
(2012-02-16)The chemotherapy of malign tumours is severely restricted due to severe side effects of the available anticancer agents. A novel approach to overcome these limitations is the Antibody ... -
Oxygen Bridged Metal Systems: Heterometallic Compounds Containing Main Group Metal, Transtion Metal and f-Elements
(2011-10-31)This dissertation lays emphasis mainly on the synthesis and structural studies of oxygen bridged heterobi- and trimetallic complexes containing main group metal, transition metal and ... -
Palladium(II)-katalysierte Domino-Reaktionen zur enantioselektiven Synthese von Confluentin, Daurichromen- und Rhododaurichromansäure Untersuchungen zur Synthese von Aglaroxin A
(2011-04-28)This thesis is about Palladium(II) catalysed Domino Reactions for the enantioselective Synthesis of Confluentin, Daurichromenic and Rhododaurichromanic acid. These substances were isolated ... -
Experimental Electron Density Determination of Unconventionally Bonded Boron
(2009-07-22)Two major aims have been pursued in the course of this thesis. On the one hand, reasons for the different reactivities of two Lewis acids based on tris(pentafluorophenyl)borane, namely ... -
Synthese, biologische Evaluation und Untersuchung des Wirkmechanismus neuartiger Duocarmycin-Analoga für eine selektive Krebstherapie
(2009-03-24)Despite considerable efforts towards the development of efficient cancer therapies, most anti-cancer agents applied so far in the clinic cause severe side effects because their cytotoxic ... -
Entwicklung katalytischer Kreuzkupplungs- und Hydroaminierungsreaktionen
(2008-11-13)In recent years great efforts have been taken for the development of highly active catalysts in the field of hydroamination- and cross-coupling-reactions. However, there is still a lack of ... -
Synthesis of Diverse Polyfunctional Amides as Precursors to Potentially Interesting Peptidomimetics
(2008-10-22)First chapter is dedicated to the applying of the Ugi multicomponent reaction for the synthesis of the compound containing small ring systems such as cyclopropane and its structure ... -
Totalsynthese von Camptothecin
(2008-10-22)The pentacyclic alkaloid camptothecin exhibits pronounced cytotoxicity. Within the framework of structure-property-relationship studies irinotecan (camptosar®) and topotecan (hycamtin®) as ...