Browsing Fakultät für Chemie (inkl. GAUSS) by Advisor & Referee "Zeeck, Axel Prof. Dr."
Now showing items 1-20 of 44
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Isolation, Purification and Structure Elucidation of New Secondary Metabolites from Terrestrial, Marine, and Ruminal Microorganisms
(2012-12-19)The search for microorganisms useful in agriculture, agroalimentary and pharmaceu-tical industries requires the exploration also of ecological niches. Thus, within this background, the rumen (one of the four stomach parts ... -
Bandamycin as New Antifungal Agent and further Secondary Metabolites from Terrestrial and Marine Microorganisms
(2012-05-03)In this study, eight terrestrial and two marine bacteria, and four endophytic fungi have been investigated chemically and pharmacologically, out of which a total of fourty-eight secondary metabolites were isolated. ... -
Studien zur Ansamitocin-Biosynthese sowie Sekundärstoffproduktion durch mikrobielle Interaktion
(2009-06-23)This thesis is structured in four separate sections. The main part is about biosynthetic investigations of Ansamitocin, a high-potent antitumor agent belonging to the family of the maytansins. ... -
Aqabamycins, Rare Nitro Maleimides and other Novel Metabolites from Microorganisms; Generation and Application of an HPLC-UV-ESI MS/MS Database
(2009-06-04)The battle to improve the quality of life by finding cures against diseases and to extend the life expectancy of mankind is still one of the priorities in natural products chemistry. Al-though ... -
Synthese und Anwendung eines radioaktiven Photoaffinitätslabels zur Wirkortbestimmung von Naturstoffen sowie Beiträge zur Totalsynthese des Collinolactons
(2009-05-05)Starting form Dibromobenzene, an effective synthesis of a radioactive labeled photoaffinity-probe was realized. By using a double-silylated diaziridine as an intermediate the first direct ... -
Struktur und Biosynthese von Spirodionsäure und Kirromycin aus Streptomyces sp.
(2009-04-09)The first project is about the investigation of the biosynthesis of the novel microbial metabolite spirodionic acid and its absolute stereoconfiguration. Within the scope of these biosynthetic ... -
Nafisamycin, Cyclisation Product of a New Enediyne Precursor, Highly Cytotoxic Mansouramycins, Karamomycins Possessing a Novel Heterocyclic Skeleton and Further Unusual Secondary Metabolites from Terrestrial and Marine Bacteria.
(2009-03-19)The search for new medically active compounds to overcome the countless diseases is one of the most relevant objectives worldwide. Medicinal plants were used previously in the traditional ... -
Unusual Sesquiterpenes: Gorgonenes and Further Bioactive Secondary Metabolites Derived from Marine and Terrestrial Bacteria.
(2009-03-16)An increasing number of infectious diseases is still not curable as many organisms are showing antibiotic resistance which urges the development of new medicaments to combat them. Natural ... -
New and Bioactive Secondary Metabolites from Ma-rine and Terrestrial Bacteria: Ramthacin A, B, C, and Polyene Macrolides from Genetically Modified Bacteria
(2009-01-09)Natural products have provided the major sources of chemical diversity for phar-maceutical discoveries for many decades. For clinical application to treat human dis-eases in almost all ... -
Total Synthesis of Various Hormaomycin Analogues with Modified Amino Acid Residues
(2008-07-28)Hormaomycin 1 and its all-peptide aza-analogue 53 were synthesized in quantities of 39 and 34 mg respectively, using the protocol developed by B. Zlatopolskiy, to have enough material for ... -
Metagenom-Technologie zur Wirkstoffsuche sowie Untersuchungen der Iromycine aus Streptomyces sp.
(2008-01-24)The present thesis deals with the screening for bioactive natural products and detailed studies of the group of iromycin polyketides to address the questions of biosynthesis, biological ... -
Sekundärstoffe aus endophytischen Pilzen mariner Habitate und Abbaureaktionen an Simocyclinon D8
(2008-01-09)This thesis deals with the isolation, characterization und chemical derivatization of natural products. Most of the described metabolites show a high potential biological activity which is ... -
Zur Biosynthese des Borrelidins sowie Isolierung und Strukturaufklärung von Sekundärmetaboliten aus marinen und terrestrischen Mikroorganismen
(2007-11-06)The relevance of natural products in pharmacological research is now after a long period again gaining more and more attention. Different aspects of natural product research are covered by ... -
Protein NMR studies of two systems involved in bacterial pathogenicity
(2006-12-04)The present work provides new structural information about bacterial proteins involved in transcription regulation and protein secretion, as well as a contribution to the improvement of ... -
Beiträge zur Biosynthese der antiparasitären Naturstoffe Hormaomycin und Borrelidin sowie Strukturaufklärung von Sekundärmetaboliten aus Actinomyceten
(2006-11-29)The core of the present thesis deals with studies of the natural products hormaomycin and borrelidin. Furthermore the isolation and structure elucidation of secondary metabolites from ... -
Struktur und Biosynthese von Collinolacton aus Streptomyces sp. und Beiträge zum Screening neuer Wirkstoffe
(2006-10-16)The cyclodecatrien collinolactone is a new microbial natural product from Streptomyces sp. Gö 40/10 and represents a hitherto unknown chemical class of substances. The structure elucidation ... -
Synthese und Untersuchung von Alanyl-PNA Oligomeren und deren Einfluß auf β-Faltblatt Strukturen
(2006-08-01)The activity and properties of proteins mainly depend on the three-dimensional arrangment of their secondary structure elements and their conformation. Conformational changes as well as ... -
Untersuchung der synaptischen Neurotransmitterfreisetzung mit kombiniert elektrophysiologischen und bildgebenden Verfahren
(2006-04-25)Neuronal networks in the brain are comprised of a mixture of excitatory and inhibitory neurons. The excitatory and inhibitory cells play distinct roles in the functional network since the ... -
Hoch cytotoxisches Kettapetin, Bhimamycine mit ungewöhnlichen Chromophoren und weitere neue Sekundärstoffe aus terrestrischen und marinen Bakterien
(2006-02-27)Nature is a source of medicinal agents since thousands of years, and an impressive number of modern drugs has been isolated from natural habitats, many based on their use firstly in traditional ... -
Pseudo-helicale und helicale Primärstrukturen aus spiroanellierten vier- und fünfgliedrigen Ringen: Synthesen und chiroptische Eigenschaften
(2006-01-24)The objective of this dissertation is a comparative study of the chiroptical properties of 1,2-spiroannulated helical hydrocarbons of three-, four- and five- membered rings. Towards this ...