Blättern Fakultät für Chemie (inkl. GAUSS) nach "Diederichsen, Ulf Prof. Dr." Betreuer
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Beta-Peptide Helices As Transmembrane Domains: Aggregation, Recognition and Lipid-Peptide Interaction
(2019-01-25)Plasma membranes are considered as the primary regulatory unit essential for efficient functioning of a cell. These membranes separate the inner part of the cell from the extracellular world as well as acts as a barrier ... -
Design and synthesis of multifunctional ligands to study and prevent aggregation processes in Amyotrophic Lateral Sclerosis proteins
(2021-02-22)Amyotrophic lateral sclerosis (ALS) is an incurable lethal disease that affects motor neurons and its heterogeneity is reflected in various mutations among the sporadic ALS (sALS) and familial ALS (fALS) disease types. ... -
Determinants of water and ion permeation through nanopores studied by Molecular Dynamics simulations
(2008-05-27)Membrane channels facilitate the transport of matter through the cell membrane, and therefore play a crucial role in life. The knowledge of the structure-permeability relationships in model channels is essential for the ... -
Development of Zinc-Finger-Based Artificial Restriction Endonucleases and Fluorescent Peptidyl Metal Sensors
(2016-11-17)Zinc finger proteins are ubiquitous in the cellular environment having an excessive diversity and performing variable tasks. Their outstanding capability to develop a sequence-specific bond to deoxyribonucleic acid (DNA) ... -
Dynamics, Intermolecular Interactions, and Organization of Transmembrane β-Peptides
(2018-02-01)Cellular membranes contain a vast variety of proteins, which are practically required for every vital mechanism, such as selective transportation of ions and organic molecules, cell-cell recognition and signal transduction.[1] ... -
Hybrids of SNARE Transmembrane Domains and Artificial Recognition Motifs as Membrane Fusion Inducing Model Peptides
(2018-03-13)Protein mediated fusion of membranes is a crucial biological process. For instance, SNARE (soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein receptor) proteins are involved in neuronal exocytosis. However, ... -
Investigation of Peptidic Templates for Bioorthogonal Ligations
(2021-08-16)One of the biggest challenges for biochemical researchers in the postgenomic era remains the elucidation of structure-activity relationships in proteins. While many proteins can be routinely produced by recombinant protein ... -
Investigation of the Linker Region of Coiled Coil SNARE-Analoga and Membrane Composition on Vesicle Fusion
(2021-03-09)SNARE (soluble N-ethylmaleimide-sensitive-factor attachment receptor) proteins play a major role in membrane fusion processes in many organisms. As these proteins form a sophisticated tetrameric coiled coil complex, many ... -
Metal containing peptides as specific DNA binders
(2016-01-29)This doctoral thesis involves design and synthesis of small model peptides based on appended domains of DNA binding proteins that are found to be crucial in generating a particular cellular response or function. The model ... -
Modification of transmembrane peptides to probe SNARE-induced membrane fusion and cross-presentation of membrane-buried epitopes
(2021-02-19)Membrane proteins play an important role in cellular function as receptors, transporters, anchors, and catalysts. Despite constituting 20-30% of the human proteome only 3 % of all characterized proteins are membrane proteins ... -
Organisation and Recognition of Artificial Transmembrane Peptides
(2016-11-15)A various number of cellular key functions such as signalling and transport are mediated by membrane proteins, which are either adhesively bound to the membrane surface or exhibit transmembrane domains. Many transmembrane ... -
Post-Synthetic DNA-Functionalization Based on DNA-Templated Dynamic Chemistry
(2015-06-26)With the growing field of DNA technology there is an increasing demand for new modifications of DNA, which improve its versatility and promote the DNA as a fundamental scaffold for a wide field of applications like catalysis, ... -
Prebiotic Synthesis of Inorganic Pyrophosphate (PPi) Driven by a Geochemical Redox Reaction
(2021-10-21)In all extant organisms adenosine triphosphate (ATP) is the energy carrier and transmitter of free energy from exergonic to endergonic processes. Since ATP is a complex molecule, it was unlikely available on prebiotic ... -
Probing SNARE-Induced Membrane Fusion Using Peptidic Model Fusogens
(2022-11-10)In this thesis, SNARE analogues with artificial recognition units made of either coiled-coil sequences or peptide nucleic acid (PNA) oligomers were synthesized. By applying FRET-based liposome fusion assays, the fusogenic ... -
Self-Organization of β-Peptide Nucleic Acid Helices for Membrane Scaffolding
(2019-08-06)In a vast number of cellular processes interactions between membranes and proteins are essential, resulting in the lipid bilayer being interspersed immensely with proteins. Apart from catalytic or signaling functions, a ... -
Synthese und Untersuchung von Alanyl-PNA Oligomeren und deren Einfluß auf β-Faltblatt Strukturen
(2006-08-01)The activity and properties of proteins mainly depend on the three-dimensional arrangment of their secondary structure elements and their conformation. Conformational changes as well as ... -
Synthese und Untersuchung von Derivaten des Azobenzols mit Silananker zur Darstellung photoschaltbarer Oberflächen
(2013-07-09)The aim of this work is the synthesis of derivatives of azobenzene with silane anchor to form photoswitchable surfaces. This is an approach to create photoswitchable surfaces in a single-step reaction to functionalize ... -
Synthese und Untersuchung von Nukleobasen-funktionalisierten Peptiden
(2006-08-17)This thesis dealt with the properties of nucleobase-functionalized peptides. Influences of aromatic sidechains on the structure and aggreagation of peptides could be shown. The knowledge ... -
Synthesis and Investigation of Nucleobase Functionalized β-Peptide as SNAREs Model System for Membranefusion
(2015-07-22)In this work, the novel simplified SNARE-mimicking systems consisting of TMD/linker segments of the natural membrane-bound SNARE proteins (syntaxin-1A and synaptobrevin 2) with a nucleobase functionalized β-peptide (β-PNA) ... -
Synthesis of fluorescent toxin and nucleotide derivatives to specifically address membrane proteins
(2015-07-15)Within this project, new tools for in vivo/in vitro labelling were developed and investigated, which may be utilized in the future to elucidate structures, localisation and distinct processes of biomolecules in their native ...