Browsing Fakultät für Chemie (inkl. GAUSS) by Advisor "Sheldrick, George M. Prof. Dr."
Now showing items 1-20 of 24
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Algorithms for Crystal Structure Determination in Macromolecular Crystallography
(2019-11-25)X-ray crystallography has been the leading technique for structure determination since the discovery of the diffraction of X-rays by crystals by Max von Laue. In this thesis the crystal structure of human ceroid lipofuscinosis ... -
Crystal Structure of Wind, a PDI-Related Protein Required for Drosophila melanogaster Dorsal-Ventral Development
(2003-11-17)Wind is a key factor to trigger dorsal-ventral patterning in the Drosophila embryo development. Genetic experiments indicate that Wind is required for targeting the dorsal-ventral ... -
Crystal Structures of a Bacterial Isocitrate Dehydrogenase and the Human Sulfamidase
(2015-01-09)In an X-ray crystallographic experiment, intensities and directions of X-rays scattered by electrons in a crystal are measured. However, the relative phase information in the interference pattern is lost. If we knew the ... -
Crystallographic and modeling studies of intermolecular interactions of biological interest
(2004-06-07)Three projects were investigated in the current thesis. In the first part, the binding of the anticancer drug 7-Aminoactinomycin-D to the non-complementary DNA 5'-TTAGBrUT-3' has been studied ... -
Crystallographic studies on DNA in complex with antibiotics and effects of anisotropic scaling on structure solution
(2008-12-01)This work investigates the structure of complexes between DNA and antibiotics discussing the crystal structures of d(AACCGGTT)-trioxacarcin, d(CGTACG)-trioxacarcin and d(ACGTACGT)-echinomycin. ... -
Crystallographic studies on Echinomycin bisintercalation on DNA and an alternating D-alanyl,L-homoalanyl PNA.
(2005-12-09)SUMMARYStructures of echinomycin in complex with double stranded DNAs. The structure of complexes between the antibiotic echinomycin and different short DNA duplexes have been ... -
Kristallographische Analyse von pathologischen Kristallen, Periplasmischen dömane von ligandfreien CitA Sensor Kinasen und PDI-verwandten Chaperone
(2006-11-08)The current work reports on developing methods to elucidate crystal structure of nonmerohedrally twinned protein crystals and analysis of structures of different proteins that mediate signal ... -
Die Kristallstruktur der α-Amylase A aus dem hyperthermophilen Bakterium Thermotoga maritima MSB8
(2003-04-03)α-Amylases catalyze the hydrolytic cleavage of α-glycosidic linkages in starch, glycogen and a number of other related compounds and play an important role in the metabolism of plants, ... -
Kristallstrukturen der Aldose-Reduktase und der C2A-Domäne von Rabphilin3A sowie Überprüfungen neuer Restraints.
(2006-11-06)The high resolution (0.82 Å) structure of Aldose Reductase (an enzyme implicated in the polyol pathway) is presented. The aim of the work was a careful inspection of the model with particular ... -
Kristallstrukturen der C2B-Domäne von Rabphilin-3A und der PP2C-ähnlichen Phosphatase tPphA von Thermosynechococcus elongatus BP-1
(2006-09-28)The first part of this thesis deals with the x-ray crystal structure of the C2B domain of Rabphilin-3A, which includes part of the linker region between the C2A and C2B domain. The second ... -
Kristallstrukturuntersuchungen zum Katalyse- und Regulationsmechanismus der Tyrosin-regulierten 3-Deoxy-D-arabino-Heptulosonat-7-Phosphat-Synthase aus Saccharomyces cerevisiae
(2003-08-06)The ability to synthesize the aromatic amino acids tyrosine, phenylalanine and tryptophan is confined to prokaryotes, yeast, algae and plants. The first common step in biosynthesis for ... -
Mersacidin-analoge Typ-B-Lantibiotika
(2000-10-16) -
New Applications of the Invariom Database
(2017-03-29)Three new applications of the Invariom database have been developed and discussed. All applications are in the field of chemical crystallography or molecular modeling. As prerequisite, the invariom database itself ... -
Optimising His-tags for purification and phasing
(2011-07-26)Rekombinant expremierte Proteine können mit einer zusätzliche Aminosäuresequenz am C- und/oder N-Terminus, dem Protein-Tag, hergestellt werden. Bei einer bestimmten Gruppe dieser Tags erlaubt ... -
Practical approaches to macromolecular X-ray structure determination
(2011-11-21)The X-ray structure determination of macromolecules is unsurpassed in precision and detail. However, such structures cannot be derived directly from X-ray diffraction data. Phases and a ... -
Probleme der modernen hochauflösenden Einkristall-Röntgenstrukturanalyse
(2001-05-23)This thesis investigates some of the major problems of modern X-ray structure analysis, from crystallisation through data-collection and structure refinement to model validation. Giving ... -
Residual density validation and the structure of Labyrinthopeptin A2
(2009-04-21)The present work is divided into two main parts. The first part deals with the analysis and validation of the residual density. For the quantification and analysis the concept of the fractal ... -
Roentgenstrukturuntersuchungen an Glycopeptid-Antibiotika und ihren Komplexen mit Zellwandpeptiden Gram-positiver Bakterien
(2000-12-15)In der vorliegenden Arbeit werden Röntgenstrukturuntersuchungen an Glycopeptiden vorgenommen. Dabei gliedert sich die Dissertation in zwei Teile. Der erste Teil beschäftigt sich ... -
Sticky triangles: New tools for experimental phasing of biological macromolecules
(2010-12-07)X-ray crystallography is the prime method for the elucidation of three-dimensional molecular structures. It enables the structure determination of biological macromolecules such as proteins ... -
Structure determination of peptides with antimicrobial action
(2004-07-28)Peptide antibiotics belonging to three different families were investigated using X-ray crystallography. The peptaibol antibiotics cephaibol A, B and C gave well-diffracting crystals and ...