Browsing Fakultät für Chemie (inkl. GAUSS) by Referee "Diederichsen, Ulf Prof. Dr."
Now showing items 1-20 of 94
-
A Force Spectroscopy Setup to Mimic Cellular Interaction Processes
(2013-06-21)The main objective of this thesis was to establish a biophysical model system that permits to quantify forces involved in cell-cell contacts and cell-substrate-adhesion in a native-like fashion. For this purpose, colloidal ... -
Aggregation Study on Lithiated Five-membered Heterocycles – Towards the Pentuple Ion
(2014-01-30)The main work of this thesis focuses on the elucidation of the aggregation of 2-thienyllithium, methyl-substituted 2-thienyllithium and 2-furyllithium in the solid state and in solution. The addition of an adequate donor ... -
Allene, Dihydronaphthalenon-Derivate und andere Sekundärmetabolite aus Pilzen mariner Habitate sowie Beiträge zu deren Biosynthese
(2004-12-15)The aim of this thesis was the isolation and structure elucidation of novel natural products from marine fungi as well as studies of their biosynthesis.Twelve fungal strains from marine ... -
Asymmetrische Allylierung von prochiralen Ketonen und deren Anwendung in der Synthese von Pinnatolid und Furopinnatin
(2012-07-30)Allylation reactions are one of the most frequently employed C–C bond formation reactions which are often used in the synthesis of natural compounds. There are many procedures known for asymmetric allylation of aldehydes ... -
Ein Baukastensystem zum universellen Aufbau kleiner rigidifizierter Peptidomimetika und spirocyclopropanierter Wirkstoffanaloga
(2005-10-28)In contrast to the various synthetic accesses to biologically active peptidomimetics developed by other groups, we start from a single readily available class of building blocks. As in a ... -
Beiträge zur Biosynthese von Strobilurin A und Oudemansin A sowie Gewinnung neuer halogenierter Strobilurine durch vorläufer-dirigierte Biosynthese
(2005-09-26)The integral part of this thesis are studies of the biosynthesis of the antifungal strobilurin A as well as experiments to modify the metabolite by precurser directed biosynthesis.Earlier ... -
Beta-Peptide Helices As Transmembrane Domains: Aggregation, Recognition and Lipid-Peptide Interaction
(2019-01-25)Plasma membranes are considered as the primary regulatory unit essential for efficient functioning of a cell. These membranes separate the inner part of the cell from the extracellular world as well as acts as a barrier ... -
Bifunctional Thiourea-Based Organocatalysts for Asymmetric C-C Bond Formation Reactions: Strecker, Nitro-Michael, Mannich
(2007-12-11)A variety of new thiourea-based organocatalysts were synthesized and tested on different important C-C bond forming reactions: Strecker-reaction, Michael-addition, and Mannich-reaction. The ... -
Bioinspired Activation of Oxygen with Pyrazole-Supported Dinuclear Copper Complexes
(2016-10-10)A series of compartmental pyrazole-bridging ligands were successfully used to gain insights into copper-mediated dioxygen activation chemistry, and thus expand on the proven potential of these organic scaffolds for emulating ... -
Biomimetische Oxidationsreaktionen mit zweikernigen Kupferpyrazolatkomplexen
(2003-11-25)A series of dinuclear copper (II) complexes with different pyrazolate ligands was synthesized and structurally characterized as biomimetic model complexes of the enzyme Catechol oxidase. ... -
C<sub>2</sub>-Symmetric Pyrazole-Bridged Ligands and Their Application in Asymmetric Transition-Metal Catalysis
(2016-06-03)Within the scope of this thesis the synthesis of a plethora of examples of in total three types of C2-symmetric pyrazole-bridged ligand systems (namely PyrBOX, PyrBPyBOX and ProPyrazole) could be established ... -
Characterization of the amyloid precursor of alpha-synuclein by NMR spectroscopy
(2008-11-04)A number of human neurodegenerative diseases, including Alzheimer"s and Parkinson"s diseases (PD), are associated with the deposition of proteinaceous aggregates known as amyloid fibrils. ... -
Dehydrorabelomycin-1-O-α-L-rhamnopyranoside, Actinofuranone C and Further New Bioactive Secondary Metabolites from Terrestrial Streptomyces spp.
(2011-09-22)Natural products have been used to combat infectious diseases since ages. However, increased resistance to existing antibiotics and emergence of new diseases stimulated the development of ... -
Design and Characterisation of Multifunctional Tools for the Elucidation of the Cu+ Chemistry in Alzheimer`s Disease
(2013-09-06)Alzheimer’s disease is the most common neurodegenerative disease in the world. Alzheimer’s disease is clinically characterised by decreased cognitive performance and pathologically characterised by formation of fibrillar ... -
Design and synthesis of multifunctional ligands to study and prevent aggregation processes in Amyotrophic Lateral Sclerosis proteins
(2021-02-22)Amyotrophic lateral sclerosis (ALS) is an incurable lethal disease that affects motor neurons and its heterogeneity is reflected in various mutations among the sporadic ALS (sALS) and familial ALS (fALS) disease types. ... -
Design and synthesis of small organic molecules to stabilize ALS-associated SOD1 mutants
(2021-06-25)Amyotrophic Lateral Sclerosis is a globally occurring neurodegenerative disease with serious implications for the patient’s life as well as imposing a heavy economic burden both on the affected individuals and society. Due ... -
Development and application of NMR methods for challenges in drug discovery
(2013-05-03)NMR spectroscopy plays an important role in all stages of the drug discovery process. Namely in the structure elucidation of natural products, synthetic ligands and metabolites, as well as a high-throughput screening ... -
Development and Application of NMR-methods for Structural Investigations of Small Molecules and Proteins
(2007-05-29)The elucidation of the relative stereochemistry of asymmetric centers of organic molecules is an important challenge in chemistry since it requires the simultaneous determination of ... -
Development of Zinc-Finger-Based Artificial Restriction Endonucleases and Fluorescent Peptidyl Metal Sensors
(2016-11-17)Zinc finger proteins are ubiquitous in the cellular environment having an excessive diversity and performing variable tasks. Their outstanding capability to develop a sequence-specific bond to deoxyribonucleic acid (DNA) ... -
Directing macromolecular assemblies by tailored surface functionalizations of nanoporous alumina
(2011-05-19)Anodic aluminum oxide (AAO) is a nanoporous material with parallel, hexagonally-ordered, cylindrical pores running straight through the material s thickness. A method to deposit highly ...