Dokumente Fakultät für Chemie (inkl. GAUSS) nach Gutachter "Zeeck, Axel Prof. Dr."
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Anwendung der Fluoreszenz-Korrelations-Spektroskopie zur Untersuchung dynamischer Prozesse in lebenden Zellen
(2001-05-09)In this thesis the Fluorescence Correlation Spectroscopy (FCS) technique is applied to cell-physiologically relevant reaction and diffusion problems in living cells. In the nucleus as well ... -
Aqabamycins, Rare Nitro Maleimides and other Novel Metabolites from Microorganisms; Generation and Application of an HPLC-UV-ESI MS/MS Database
(2009-06-04)The battle to improve the quality of life by finding cures against diseases and to extend the life expectancy of mankind is still one of the priorities in natural products chemistry. Al-though ... -
Aufbau einer HPLC-UV-ESI-MS/MS-Datenbank und ihre Anwendung im Screening arktischer und antarktischer Meeresbakterien
(2005-10-21)Microorganisms from uncommon habitats are an attractive source for chemically and biologically outstanding natural compounds, for the interaction between different species in complex living ... -
Bandamycin as New Antifungal Agent and further Secondary Metabolites from Terrestrial and Marine Microorganisms
(2012-05-03)In this study, eight terrestrial and two marine bacteria, and four endophytic fungi have been investigated chemically and pharmacologically, out of which a total of fourty-eight secondary metabolites were isolated. ... -
Beiträge zur Biosynthese der antiparasitären Naturstoffe Hormaomycin und Borrelidin sowie Strukturaufklärung von Sekundärmetaboliten aus Actinomyceten
(2006-11-29)The core of the present thesis deals with studies of the natural products hormaomycin and borrelidin. Furthermore the isolation and structure elucidation of secondary metabolites from ... -
Bioactive Secondary Metabolites from Marine and Terrestrial Bacteria: Isoquinolinequinones, Bacterial Compounds with a Novel Pharmacophor
(2005-01-17)After a chemical and biological pre-screening of bacterial extracts, 17 Streptomycetes (including eleven terrestrial and six marine-derived strains) and ten North Sea bacteria (including ... -
Darstellung bor- und phosphorhaltiger Ringe durch Reaktionen von Halogenboranen und -phosphanen mit Bis(tert.-butyl-methyl)ketazin
(2004-10-22)The first part of this thesis refers to the reactions of boroles, especially substitutions of remaining halogens and dehydrohalogenation reactions. The second part deals with similarities ... -
Dynamics of the B-A Transition of DNA Double Helices
(2005-05-20)Although the B-A transition of DNA is known for about 50 years, the dynamics of this transition has not been characterized yet. Experiments with stopped flow instrument showed that the ... -
Final Elucidation of the Absolute Configuration of Hormaomycin - Total Synthesis of Hormaomycin and Analogs
(2004-09-14)This work has been focused on the synthesis of hormaomycin and analogs, and prior to that, on the assignment of the absolute structure of unusual amino acids, which comprise hormaomycin, ... -
Hoch cytotoxisches Kettapetin, Bhimamycine mit ungewöhnlichen Chromophoren und weitere neue Sekundärstoffe aus terrestrischen und marinen Bakterien
(2006-02-27)Nature is a source of medicinal agents since thousands of years, and an impressive number of modern drugs has been isolated from natural habitats, many based on their use firstly in traditional ... -
Isolation, Purification and Structure Elucidation of New Secondary Metabolites from Terrestrial, Marine, and Ruminal Microorganisms
(2012-12-19)The search for microorganisms useful in agriculture, agroalimentary and pharmaceu-tical industries requires the exploration also of ecological niches. Thus, within this background, the rumen (one of the four stomach parts ... -
Isolierung und Strukturaufklärung neuer Naturstoffe aus Bakterien und endophytischen Pilzen durch chemisches Screening
(2005-09-26)The present work deals with the isolation and structure elucidation of new secondary metabolites from bacteria and endophytic fungi, found by chemical screening. The antimicrobial and ... -
Isolierung, Strukturaufklärung und Biosynthese von Sekundärmetaboliten endophytischer Pilze aus Algen und Pflanzen mariner Habitate
(2005-10-18)The core of the present thesis is the study of endophytic fungi with regard to their production of secondary metabolites. Altogether 56 fungal strains were both chemically and biologically ... -
Metagenom-Technologie zur Wirkstoffsuche sowie Untersuchungen der Iromycine aus Streptomyces sp.
(2008-01-24)The present thesis deals with the screening for bioactive natural products and detailed studies of the group of iromycin polyketides to address the questions of biosynthesis, biological ... -
Molecular mechanisms of AMPA and kainate receptor gating and its implication in synaptic transmission
(2002-11-25)In this work we have studied the biophysical properties of AMPA and kainate receptors, which are found mainly in central synapses. AMPA receptors are thought to be tetrameric in nature. The ... -
Nafisamycin, Cyclisation Product of a New Enediyne Precursor, Highly Cytotoxic Mansouramycins, Karamomycins Possessing a Novel Heterocyclic Skeleton and Further Unusual Secondary Metabolites from Terrestrial and Marine Bacteria.
(2009-03-19)The search for new medically active compounds to overcome the countless diseases is one of the most relevant objectives worldwide. Medicinal plants were used previously in the traditional ... -
New and Bioactive Secondary Metabolites from Ma-rine and Terrestrial Bacteria: Ramthacin A, B, C, and Polyene Macrolides from Genetically Modified Bacteria
(2009-01-09)Natural products have provided the major sources of chemical diversity for phar-maceutical discoveries for many decades. For clinical application to treat human dis-eases in almost all ... -
One-pot, Two-step Queuing Cascades Involving a Heck Coupling, π-Allylpalladium Trapping and Diels-Alder Reaction
(2006-01-23)In the first part of this study, palladium catalyzed reactions of mono-substituted bicyclopropylidenes (66B E) with iodobenzene (67) in the presence of dienophiles 68a b have been performed. ...