Recent Submissions
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Exploring Transient Dialumene and Diazido-Dialane: Low Oxidation State Aluminium Chemistry based on a Hybrid Ligand
(2025-06-12)This thesis focuses on the exploration and development of the hybrid NacNac-Box-akin ligand, DippNac-Indole (DNI), and its application in stabilizing low oxidation state aluminium complexes. The study is structured to ... -
Axial and Equatorial Ligand Effects of Bioinspired Tetracarbene Iron Models for Heme and Non-Heme Enzymes
(2025-06-12)The selective oxidation of hydrocarbons with sustainable oxidants is still a challenging reaction in industry. In order to create a sustainable future—especially in regard of progressing climate change—finding alternative ... -
Synthesis and Adhesion Properties of E-Cadherin Mimetic Peptides
(2025-06-12)Cell adhesion molecules (CAMs) are essential for various biological processes, including tissue homeostasis and wound healing. One such molecule, the calcium-dependent protein E-cadherin, is primarily expressed at adherens ... -
C-H Bond Activation by Iridium(III) and Iridium(IV) Oxo Complexes
(2025-06-11)C−H activation by two isostructural, terminal iridium(III) and iridium(IV) oxo complexes is compared. While the driving forces for hydrogen abstraction are almost identical due to compensating contributions from H+ and e− ... -
Preorganization within a pyrazolato-bridged bis-β-diketiminato dinickel frame as a key tool to access terminal sulfides and synergistically stabilized intermediates for acetyl-CoA synthase mimetic thioester formation
(2025-05-21)Bimetallic complexes are frequently employed in natural enzymes and in applications such as imaging, targeting, and catalysis, in order to exploit the synergy between two metal centers or to combine different functionali ... -
Investigation of Nuclear Hyperfine Coupling in H2 Heterodimers Using Rotational Spectroscopy
(2025-05-20)Rotational spectroscopy of gas phase compounds is a powerful technique for structure determination through the unique moments of inertia of a molecular system. It is sensitive angular momentum coupling; therefore, complicated ... -
Synthesis of Artificial Nucleotides for Biological Applications
(2025-05-20)This thesis explores the synthesis of nucleotides, the building blocks of DNA and RNA, two essential molecules in living cells. One project focused on developing a more effective ligand for orotidine-5’-monophosphate ... -
Transient Triplet Metallopnictinidenes
(2025-04-30)Nitrenes (N–R) are subvalent key intermediates in organic synthesis and have been extensively studied. The heavier pnictinidene analogues have also attracted great interest, but comprehensive investigations that systematically ... -
Enantioselective Electrochemical C–H Activation with Cobalt, Nickel, and Iron
(2025-04-04)The enantioselective functionalization of otherwise inert C–H bonds to assemble chiral molecules has become an increasingly powerful tool in molecular synthesis. In spite of significant advances in this domain, the ... -
Computational studies and embedding strategies for the characterisation of a novel covalent bond in proteins
(2025-03-25)This work offers a comprehensive study on the bond properties of a noval covalent bond between three electronegative atoms nitrogen, oxygen and sulfur (NOS), which is found in proteins as crosslink between lysine and ... -
Synthesis of Pyrrolo[1,2-c]pyrimidine-1-ylidenes: Coordination Chemistry and Application as Ancillary Ligands for Metal Catalysis
(2025-03-20)N-heterocyclic carbenes (NHCs) represent an important class of ancillary ligands for transition metal catalysis due to their strong binding character and generally simple syntheses procedures. One important feature of these ... -
Cooperative Activation of Small Molecules on Preorganized Dinuclear Cobalt Complexes
(2025-03-14)The coordination chemistry of late-transition-metal dinitrogen complexes remains a topic of considerable interest. In this study, a pyrazolate-based dinucleating nacnac ligand was employed to construct a series of bimetallic ... -
Cell-Substrate Distance Fluctuations and their Impact on Wound Healing in Epithelial Tissues
(2025-03-13)Cellular movements are fundamental to a wide array of physiological processes essential for an organism's development, maintenance, and repair. Understanding the underlying mechanisms that regulate these movements provides ... -
Investigation of Framework-forming Aggregation of Peptide Helices on Membrane Surfaces
(2025-02-14)This study presents the development and investigation of peptide-based systems designed to induce controlled aggregation on membrane surfaces, potentially facilitating cell signaling by promoting lipid raft formation. The ... -
Identification and Characterization of Intermediates in Transmetalation Reactions from Boron to Lithium and Copper
(2025-02-14)Transmetalation is a crucial elementary step in cross-coupling reactions. In this context, boron nucleophiles are especially popular and versatile, however, the fundamental details of transmetalation reactions involving ... -
Development of a Bone Adhesive Material based on Diazirinyl-Collagen Mimetic Peptides
(2025-02-05)The treatment of small and inaccessible bone fractures with metallic implants is challenging. One potential solution to this issue is the use of an adhesive to adhere the affected fragments. In the search for new biocompatible ... -
On the chemistry of sulfur: Development of NOS bridge model systems and Stereoretentive 2,3-bis(trifluoromethyl)cyclopropanation of heteroarenes via sulfonium salts
(2025-02-05)This thesis presents research conducted across two distinct projects in sulfur chemistry. The first project focused on the synthesis of model systems based on biphenyl, xanthene, and triazamacrocyclic scaffolds to investigate ... -
Enantioselective Synthesis and Postsynthetic Functionalization of Thiahelicenes and their Oxa-analogues
(2025-01-30)Based on the Alcarazo group’s experience in enantioselective Au(I)-catalyzed synthesis of (hetero)helicenes employing alkyne hydroaryration reactions, the gold precatalyst 188c, combining a chiral BINOL-derived backbone ... -
Quantitative Estimation of Cell Mechanical Cues using Elastic Micropillars
(2025-01-24)Within the intricate landscape of the cellular microenvironment, the inter- play between biochemical and physical signaling emerges as a decisive force shaping the physiology and functions of living cells. Recent insights ... -
Reductive Small Molecule Transformations with Pyrazolate-Based Bimetallic Complexes
(2025-01-23)The activation of small molecules (NO, O2, CO, CO2, N2, etc.) is important in a multitude of fields such as biology, medicine and industrial catalysis. Many synthetic catalysts were inspired by the active sites of ...