Blättern Fakultät für Mathematik und Informatik (inkl. GAUSS) nach "Wingender, Edgar Prof. Dr." Betreuer
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A Bioinformatics Pipeline for Identifying Dysregulated Pathways in Cancer from Comparative RNA-Seq Transcriptome Analysis
(2022-04-07)Cancer is characterized as a multifactorial disease which undergoes genetic and epige- netic changes during invasive tumor growth. Thus, numerous tumor samples have been profiled using high-throughput sequencing technologies ... -
Application of A Novel Triclustering Method in Analyzing Three Dimensional Transcriptomics Data
(2015-06-19)Due to the advancement of microarray technology over the last decade, it is feasible to monitor the gene expression dynamics not only over a set of replicates but also either a set of time points or doses of chemical ... -
Constructing Temporal Transcriptional Regulatory Cascades in the Context of Development and Cell Differentiation
(2020-07-14)Cell differentiation is a complex process orchestrated by sets of regulators appearing at precise temporal points, resulting in regulatory cascades that affect the expression of broader sets of genes, ending up in the ... -
Detektion und Analyse synergistischer Einflüsse multipler Stimuli auf zelluläre Signaltransduktionsnetzwerke in Säugetieren
(2013-11-21)Simultaneously working signals affect the behavior of organisms at systems level. Different signals have to be integrated and evaluated simultaneously by the cell. Synergistic interactions are one possibility how a cell ... -
Information theoretical approaches for the identification of potentially cooperating transcription factors
(2019-08-08)Transcription factors (TFs) are a special class of proteins that usually bind regulatory DNA regions such as promoters and enhancers in order to control the expression of their target genes. Today, it is well known that ... -
Knowledge Integration and Representation for Biomedical Analysis
(2021-02-25)Information-based health systems aimed at improving clinical decision-making are appealing as they are able to cope with the rising amount of information that clinicians are experiencing and provide a framework for ... -
Vorhersage, Analyse und Bedeutung charakteristischer Transkriptionsfaktor-Bindestellen und deren potentielle Masterkontrollfunktion in der transkriptionellen Genregulation
(2021-10-19)In eukaryotes, transcriptional gene regulation is controlled by a set of transcription factors (TFs) and co-factors. Most TFs bind to specific DNA sequences. These binding sites are called transcription factor binding ...