Browse by type "cumulativeThesis"
Now showing items 1-20 of 23
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Novel machine learning solutions for precision medicine - from causal inference to cellular perturbations and interactions
(2024-10-04)Optimal therapy of complex diseases necessitates a shift from one-size-fits-all solutions towards personalized treatment plans. To achieve this, it is crucial to understand the casual effect of medical interventions, such ... -
Statistical Optimal Transport and its Entropic Regularization: Compared and Contrasted
(2024-04-26)In recent years, statistical methodology based on optimal transport witnessed a considerable increase in practical and theoretical interest. A central reason for this trend is the ability of optimal transport to compare ... -
Statistical and Structural Aspects of Unbalanced Optimal Transport Barycenters
(2022-10-20)Optimal transport (OT) has seen a stellar rise in interest and relevance in the past two decades. More recently, severe limitation of OT have started to surface. Two key factors prevent it from becoming a standard tool in ... -
Automated Static Analysis Tools: A Multidimensional view on Software Quality Evolution
(2022-08-31)Software use is ubiquitous. The quality and the evolution of quality over long periods of time is therefore of notable importance. Software engineering research investigates software quality in multiple areas. One of ... -
Fast methods for metagenomic sequence search and annotation
(2022-06-16)The past two decades have seen the development of metagenomics, the study of genes and genomes of multiple organisms simultaneously. In contrast to traditional genomic techniques, which require isolating and growing ... -
Limit Laws for Empirical Optimal Transport
(2022-02-17)Optimal Transport (OT) has recently gained increasing attention in various fields ranging from biology to machine learning and mathematics. Especially OT based dissimilarity measures can be designed to respect the underlying ... -
Geometric convergence of slice sampling
(2021-10-19)In Bayesian statistics sampling w.r.t. a posterior distribution, which is given through a prior and a likelihood function, is a challenging task. The generation of exact samples is in general quite difficult, since the ... -
PHOENIX: A Premise to Reinforce Heterogeneous and Evolving Internet Architectures with Exemplary Applications
(2020-12-02)The Internet was designed primarily for sharing expensive resources through establishing point-to-point connection using dedicated IP addresses. However, it has since evolved both in complexity and its number of users. ... -
Index Theory and Positive Scalar Curvature
(2020-07-24)The aim of this dissertation is to use relative higher index theory to study questions of existence and classification of positive scalar curvature metrics on manifolds with boundary. First we prove a theorem relating ... -
Spatio-temporal reasoning for semantic scene understanding and its application in recognition and prediction of manipulation actions in image sequences
(2020-04-21)Human activity understanding has attracted much attention in recent years, due to a key role in a wide range of applications and devices, such as human- computer interfaces, visual surveillance, video indexing, intelligent ... -
Alignment-free Phylogeny Reconstruction Based On Quartet Trees
(2020-03-11)Traditional methods for phylogeny reconstruction are based on multiple sequence alignments and character-based methods. This combination of computationally expensive methods leads to very accurate results, but it is ... -
Discrete Parameter Estimation for Rare Events: From Binomial to Extreme Value Distributions
(2019-06-13)Estimating a discrete parameter from rare events is a challenging task, since observations are scarce in such situations. In this cumulative dissertation two distinct problems resulting from rare events are discussed and ... -
Inverse Problems in Propagation-based X-ray Phase Contrast Imaging and Tomography: Stability Analysis and Reconstruction Methods
(2019-06-12)Propagation-based X-ray phase contrast imaging (XPCI) and -tomography (XPCT) extend the capabilities of classical X-ray radiography and computed tomography (CT) to imaging of microscopic specimens with nanometer-sized ... -
Integrated Algorithms for Cost-Optimal Public Transport Planning
(2019-03-29)Since the demand for passenger transport is ever increasing, public transport planning is a topic of ongoing research. While single problem stages like line planning, timetabling or vehicle scheduling are already extensively ... -
Inverse Problems in Asteroseismology
(2019-03-06)Asteroseismology allows us to probe the internal structure of stars through their global modes of oscillation. Thanks to missions such as the NASA Kepler space observatory, we now have high-quality asteroseismic data for ... -
Analysis of expression profile and gene variation via development of methods for Next Generation Sequencing data
(2018-11-27)Since the last ten to twenty years, the cost of sequencing the human genome decreased continuously. Therefore the interest in RNA sequencing (RNA-Seq) rose as it can be used to discover the molecular mechanisms behind ... -
Development of novel analysis and data integration systems to understand human gene regulation
(2018-06-27)Abstract: This thesis covers a very broad range of bioinformatics methods ranging from the development of the analysis pipeline to the data integration and development of an expression atlas (database and web application ... -
On Minmax Robustness for Multiobjective Optimization with Decision or Parameter Uncertainty
(2018-04-27)Multiobjective optimization problems (MOPs) are problems with two or more objective functions. Two types of uncertainty in MOPs are distinguished, namely decision uncertainty and parameter uncertainty. Decision uncertainty ... -
Methodical and technical aspects of functional-structural plant modelling
(2017-09-26)During the last decade, functional-structural plant models (FSPM) has become a more widely accepted paradigm and tool in life sciences. The increasing demand for FSPMs raised a number of new challenges, including the ... -
Development and application of ontologies for biological applications
(2016-02-08)In the century of information technology automatic processing of knowledge is evolving to be a crucial challenge. However, it is usually not obvious to extract information from the syntax of texts. Hence, ontologies are ...