Dokumente Fakultät für Physik (inkl. GAUSS) nach Gutachter "Köster, Sarah Prof. Dr."
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Adaptive Scanning for STED Microscopy
(2020-02-06)Optical nanoscopy allows for highly specific imaging of biological tissue, cellular components and even single molecules and has therefore become an integral part of modern biomedical research. In STED microscopy, being ... -
Advanced x-ray multilayer waveguide optics
(2017-09-12)The aim of this thesis is to demonstrate that x-ray waveguide optics can be gen- eralized from a single guiding film to an array of planar waveguides, enabling more complex and controllable phenomena of field propagation ... -
Biophysics of Blood Platelet Contraction
(2013-05-21)This work is part of a project on blood platelet contraction using an innovative double approach to experiments. First, we adapted the experimental technique, traction force microscopy (TFM), to our cellular system, and ... -
Cation induced self-assembly of intermediate filaments
(2013-05-15)Cellular shape and the internal structure of living cells are defined by a dense network of three independent filament systems (actins, microtubules and intermediate filaments) termed "the cytoskeleton". Of these three ... -
Dewetting of Polymer Thin Films on Viscoelastic Substrates
(2010-03-03)In the present work, we study the wetting and dewetting phenomena on viscoelastic substrates, which are either planar or topographically structured.The main focus has been given primarily to the ... -
DNA-based molecular force sensors in cytoskeletal networks and cells
(2015-07-30)Eukaryotic cells are highly active and undergo force generating processes such as cell adhesion, migration and division. The cytoskeleton, a polymer meshwork in cells, plays an important role in these cellular processes. ... -
Dynamics of soft interfaces in droplet-based microfluidics
(2014-04-30)This doctoral thesis presents the study of di erent dynamic processes occurring at the droplet interface, and the methods implemented for their study. The objective of this work is to unravel what are the important properties ... -
Elasticity of basic structural element in anisotropic macromolecular networks
(2016-09-27)Semiflexible filaments are abundant in biological materials. From cells to the extracellular environment, these kind of filaments are found. They are important for many biological organizations and processes. The maintenance ... -
Interactions Within and Between Cytoskeletal Filaments
(2023-05-26)Cellular mechanics are determined by the cytoskeleton which consists of three different kind of biopolymers – actin filaments, microtubules and intermediate filaments – which form an intricate network. Each filament type ... -
Investigating cellular nanoscale with x-rays from proteins to networks
(2016-08-12)In this work, two macromolecules, both essential components of cells (keratin protein and DNA nucleic acid) were studied by X-ray techniques. I described the implementation and use of different methods to investigate these ... -
isoSTED microscopy for live cell imaging
(2019-05-08)Far-field fluorescence microscopy is a versatile tool for the non-invasive investigation of intracellular structures and thus for live cell imaging. This is a major advantage over other microscopy methods such as electron ... -
Liquid Crystal Microswimmers - from single entities to collective dynamics
(2016-11-15)Recently, artificial self-propelled systems at low Reynolds numbers have gained a lot of attention. The main interest lies in mimicking well-studied systems, e.g. the active Brownian motion of bacteria, or in gaining deeper ... -
Liquid Crystals in Aqueous Ionic Surfactant Solutions: Interfacial Instabilities & Optical Applications
(2014-06-02)This thesis presents the properties and applications of various liquid crystal (LC)-aqueous ionic surfactant systems. It begins with the study of micellar solubilization of different LCs in aqueous ionic micellar solutions. ... -
Localizing and tracking of single molecules with a MINFLUX-microscope for various applications
(2022-01-25)Recently MINFLUX microscopy was first published, a technique that localizes single fluorescent molecules by probing with a structured illumination excitation beam featuring a central intensity minimum. Single nanometer ... -
Localizing and tracking of fluorescent molecules with minimal photon fluxes
(2018-01-19)In this thesis MINFLUX is presented, a novel optical scheme to determine the position of individual photon emitters in space. By probing the emitter with adapted illumination profiles featuring an intensity zero, the number ... -
Low-dose, high-throughput scanning small-angle X-ray scattering of adherent mouse embryonic fibroblasts
(2022-02-24)Biological cells are highly variable: differences in e. g. gene expression emerge even among monoclonal cells in the same culture dish. The characterization of a highly variable statistical population calls for high-throughput ... -
Mechanics of Intermediate Filaments
(2014-07-02)The eukariotic cytoskeleton consists of three major filament types: actin filaments, microtubules and intermediate filaments. While the first two filament types are highly conserved, intermediate filaments vary between ... -
Mechanosensing and Symmetry of Potassium Channels Studied by Molecular Dynamics Simulations
(2018-10-02)Potassium channels are relevant in a variety of physiological processes in all three kingdoms of life. In mammals these processes including nerve signaling, heartbeat regulation, and osmotic regulation of cells. Thus a ... -
Multi-parameter assessment of mechano-sensitivity driven differentiation of human mesenchymal stem cells
(2020-12-22)What factors and conditions control stem cell differentiation is currently one of the major questions in biomedical research. What factors ultimately influence the cells’ decision is unclear but it has been shown, that ... -
Multilagenbasierte Transmissionsoptiken für die Röntgenmikroskopie
(2012-08-23)Microscopy in the x-ray regime (0,001 – 10 nm wavelength) is a well-established method filling the gap between light and electron microscopy. Focusing of x-rays using transmission optics like zone plates, spatial resolutions ...