Browsing Naturwissenschaften, Mathematik und Informatik by Referee "Brose, Nils Prof. Dr."
Now showing items 21-39 of 39
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Biochemistry and physiological role of otoferlin
(2011-11-24)In humans deafness is caused by environmental but also by genetic factors. Mutations in the gene encoding otoferlin are one genetic cause of deafness, leading to DFNB9 an autosomal recessive ... -
Synaptic Targeting of Neurotransmitter Receptors is Regulated by Neurobeachin
(2011-11-14)In neuronal network, information is transferred mainly via chemical synapses. Typically, a neuron receives thousands of inputs, which are transmitted by the activation of a large number of ... -
Isolation and characterisation of synaptic vesicles from mouse brain
(2011-08-08)All eukaryotic cells exhibit a constant turnover of membrane components via trafficking of vesicles between subcellular compartments. A classical example of a dynamic membrane delimited ... -
Untersuchungen der Funktion des Kleinhirns mit Hilfe von Mausmutanten
(2011-01-17)Analysis of cerebellar function using mouse mutans- NDRF regulates differentiation and axon development of cerebellar basket cells -The cerebellar cortex is essentially comprised of three ... -
Charakterisierung der Proteinphosphatase 1E (PPM1E) - Lokalisierung und Trunkation in Gehirngewebe und Effekte auf neuronale Morphologie in primärer Neuronenkultur
(2010-11-26)Alzheimer s disease (AD) is a progressive neurodegenerative disorder, characterized by early deficits in learning and memory with eventual loss of higher cognitive functions. Although ... -
The Role of the Ras Guanyl-Nucleotide Exchange Factor Rasgrp1 in Synaptic Transmission
(2010-10-22)Ras signaling pathways are known to regulate neuronal development and function. Ras G proteins have been implicated in the differentiation of neurons, e.g. in dendrite and dendritic spine ... -
NOVEL APPROACHES TO MODELING AND TREATMENT OF COGNITIVE DEFICITS IN NEUROPSYCHIATRIC DISEASES
(2010-10-15)Cognitive deficits and impairments of higher brain functions are the most burdening features in various neuropsychiatric disorders (e.g. Elvevag and Goldberg, 2000). Up to now, there are ... -
Expression and function of PSD-93 isoforms in hippocampal synapses
(2010-08-11)Changes in the strength of synaptic transmission are thought to underlie information processing in the brain. At excitatory synapses in the hippocampus, synaptic strength is determined by ... -
Neuroprotektion und Neurorestauration im MPTP Modell der Parkinson Erkrankung
(2010-07-01)Parkinson s disease (PD) is the most common neurodegenerative movement disorder of the basal ganglia and is characterized by a progressive loss of dopaminergic neurons in the substantia ... -
The PI5P 4-kinase ortholog PPK-2 of Caenorhabditis elegans acts in synaptic transmission and neuronal membrane trafficking
(2010-06-28)Synaptic transmission relies on the tightly regulated membrane transport between the neuronal cell body and the nerve terminal. Important regulators of membrane trafficking in neurons as ... -
Investigation of early endosomal sorting and budding
(2009-11-04)Early endosomes constitute a major sorting platform of eukaryotic cells. They receive endocytic carrier vesicles from the plasma membrane and trafficking vesicles from the Golgi complex and ... -
Functional organisation of the central complex of the grasshopper <i>Chorthippus biguttulus</i> in relation to sound production
(2008-05-27)The central complex is a major control neuropile for the situation specific selection of sound pattern of grasshoppers. The current thesis tries to investigate the role of different neurotransmitter systems in this brain ... -
NMR Spectroscopic studies of calmodulin plasticity in calcium signalling
(2008-03-18)The present work focused both in structural and dynamic studies on the ubiquitous Ca2+ signaling protein calmodulin. Calmodulin has been extensively studied both for its biological importance in the regulation of its ... -
SNARE assembly and regulation on membranes
(2006-08-01)The fusion of synaptic vesicles with the pre-synaptic plasma membrane is mediated by SNARE proteins. This work provides key insights into the behaviour of synaptobrevin, the SNARE protein ... -
Identification of Genes in the Dorsal Raphe Nucleus Regulated by Chronic Stress and Citalopram
(2006-06-16)It is known that stress, especially when it is chronic, can lead to mood disorders and changes in the serotonergic (5-HT) system, which most probably play a role in stress-induced ... -
Role of Smad-interacting Protein 1 (Sip1/Zfhx1b) in the development of the cerebral cortex
(2006-05-19)Smad-interacting protein 1 (Sip1/Zfhx1b) is a transcription factor that has been previously implicated in TGF-β/BMP signaling and in the etiology of the Mowat-Wilson syndrome. The expression ... -
The establishment and characterization of an improved cell-free assay for exocytosis in neuroendocrine PC12 cells
(2005-11-04)Regulated exocytosis in neurons and neuroendocrine cells is mediated by the SNARE proteins synaptobrevin/VAMP, SNAP-25, and syntaxin 1. During fusion, these SNAREs form a stable complex ... -
Role of the mGRIP1 homologue DGrip in the Drosophila neuromuscular system
(2005-07-05)Here, the identification and characterisation of the Drosophila homologue of the Glutamate Receptor Interacting Protein, DGrip is described. Mutants of DGrip show four scorable defects, a ... -
Targeting gene therapy to neuroinfalmmatory lesions in experimental autoimmune encephalomyelitis
(2005-03-18)The blood-brain barrier (BBB) protects the central nervous system (CNS) from harmful substances but at the same time is an obstacle to therapy by blocking the transport of drugs into brain ...