Browsing Naturwissenschaften, Mathematik und Informatik by Referee "Neher, Erwin Prof. Dr."
Now showing items 21-39 of 39
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Probing modes of vesicle docking in neurosecretory cells with evanescent wave microscopy
(2006-02-20)Secretory vesicles dock at the plasma membrane and proceed through several steps in preparation for Ca2+-triggered fusion. The molecular events between the first morphological contact with ... -
Spatial and temporal aspects of PI(4,5)P<sub>2</sub> and SNAREs in exocytosis studied using isolated membrane sheets and capacitance measurements
(2006-02-09)Ca2+-triggered exocytosis is a highly regulated process and the proteinaceous machinery mediating and regulating it has been studied in detail over the last decade. However, the participation ... -
Probing vesicle dynamics within small synapses
(2006-01-27)Sustained synaptic transmission at the hippocampal synapse (Ø∼1 μm) requires continuous exocytosis and subsequent endocytosis of synaptic vesicles (Ø∼35 nm). The kinetics of this process ... -
Veranschaulichung subzellulärer physikalischer Kräfte biochemischen und mechanischen Ursprungs mittels FRET
(2005-12-09)The cellular cytoskeleton is composed of microfilaments, intermediate filaments, microtubules and a host of accessory proteins that control its dynamics during different, cell-type and ... -
The establishment and characterization of an improved cell-free assay for exocytosis in neuroendocrine PC12 cells
(2005-11-04)Regulated exocytosis in neurons and neuroendocrine cells is mediated by the SNARE proteins synaptobrevin/VAMP, SNAP-25, and syntaxin 1. During fusion, these SNAREs form a stable complex ... -
Effect of nitric oxide and inflammatory mediators on axonal transport
(2005-11-04)Increased production of inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and reactive oxygen species by glia in the central nervous system (CNS) is a hallmark of a variety ... -
Molecular physiology of the inner hair cell ribbon synapses
(2005-08-05)During this work we investigated organization, molecular composition and function of hair cell ribbon synapses. We demonstrated RIBEYE, Bassoon and Piccolo to be components of IHC synaptic ... -
Role of the mGRIP1 homologue DGrip in the Drosophila neuromuscular system
(2005-07-05)Here, the identification and characterisation of the Drosophila homologue of the Glutamate Receptor Interacting Protein, DGrip is described. Mutants of DGrip show four scorable defects, a ... -
Structural/functional analysis of synaptotagmin 1 in synaptic transmission using hippocampal autapses
(2005-06-10)Synaptotagmin 1 is a presynaptic vesicular protein, which has been implicated as a putative Ca2+ sensor for fast neurotransmitter release in central nervous system. Structurally, it ... -
Munc18 function in large dense-core vesicle exocytosis
(2005-03-23)Neurotransmitter and hormon release is based on Ca2+ dependent exocytosis. The sequential steps of exocytosis are executed by proteins and protein complexes. Formation of the SNARE complex ... -
Targeting gene therapy to neuroinfalmmatory lesions in experimental autoimmune encephalomyelitis
(2005-03-18)The blood-brain barrier (BBB) protects the central nervous system (CNS) from harmful substances but at the same time is an obstacle to therapy by blocking the transport of drugs into brain ... -
In vivo imaging of long-term changes in the Drosophila neuromuscular junction
(2005-02-11)So far synaptogenesis could hardly be studied in its native settings. In this thesis, an assay which allows the study of synapse formation and maturation in vivo was established in a ... -
Expression and function of serotonin receptor isoforms in the respiratory system
(2005-02-09)A variety of different serotonin receptors (5-HTRs) are known to modify neuronal net-work activity through G-protein activated second messenger pathways. To obtain more information about ... -
Electrophysiological characterization of insulin secreting beta-cells in pancreatic tissue slices
(2004-11-09)In the present study a pancreatic tissue slice preparation was established to enable the characterization of insulin secreting β-cells in close to in vivo conditions. The procedure to obtain ... -
Mitochondrial metabolism in hypoglossal motoneurons from mouse – implications for amyotrophic lateral sclerosis (ALS)
(2004-03-03)Motoneurons (MNs) are selectively damaged both in human amyotrophic lateral sclerosis (ALS) and corresponding mouse models of this neurodegenerative disease. A variety of studies indicate that mitochondrial dysfunction and ... -
Charakterisierung von einer retrograden Modulation inhibitorischer synaptischer Transmission im Kleinhirn der Ratte
(2003-12-15)In recent years, a lot of interest has been given to retrograde modulatory mechanisms of synaptic transmission: in many regions of the central nervous system, substances released from ... -
Molekular-Dynamik-Simulationen zum Katalysemechanismus der Acetylcholinesterase
(2002-02-14)Acetylcholinesterase plays an important role in the signal transmission in cholinergic synapses. The aim of this work is to obtain a better insight into the catalytic reaction mechanism ... -
Statistical analysis of synaptic transmission at the calyx of Held synapse
(2001-04-25)In order to distinguish pre- and postsynaptic mechanisms contributing to short-term synaptic depression at the calyx of Held synapse in the rat auditory pathway, non-stationary EPSC fluctuation ... -
Structure and function of K<SUB>ATP</SUB>-channels in inspiratory neurons of mice
(2000-12-13)The respiratory center within the brainstem is one of the most active neuronal networks in the brain that generates rhythmic activity for lifetime. Such extreme stability requires efficient ...