Browsing Naturwissenschaften, Mathematik und Informatik by Referee "Tittmann, Kai Prof. Dr."
Now showing items 21-40 of 46
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Nitric Oxide Reactivity and Unusual Redox Properties of Biomimetic Iron-Sulfur Clusters with Alternative Cluster Ligands
(2018-05-02)This work describes the nitrosylation of biomimetic [2Fe–2S] clusters with phenylbis(benzimidazol-2-yl)methane or benzimidazolthiophenol ligands in different iron oxidation states and ligand protonation states. Mixed-valent ... -
Fatty acid oxidizing enzymes in Lobosphaera incisa
(2018-04-23)Green microalgae are a model in biotechnology because of their capacity to accumulate neutral lipids, as part of a general lipid remodeling mechanism under stress. The species L. incisa is of special interest for its unique ... -
Hybrids of SNARE Transmembrane Domains and Artificial Recognition Motifs as Membrane Fusion Inducing Model Peptides
(2018-03-13)Protein mediated fusion of membranes is a crucial biological process. For instance, SNARE (soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein receptor) proteins are involved in neuronal exocytosis. However, ... -
Dynamics, Intermolecular Interactions, and Organization of Transmembrane β-Peptides
(2018-02-01)Cellular membranes contain a vast variety of proteins, which are practically required for every vital mechanism, such as selective transportation of ions and organic molecules, cell-cell recognition and signal transduction.[1] ... -
Cytoskeletal reorganization in human blood platelets during spreading
(2017-06-21)Anucleate, human blood platelets play an important role in haemostasis to prevent excessive blood loss from a vascular damage. Their actin and microtubule (MT) cytoskeleton is especially responsible for bringing about ... -
Structure, Mechanism and Inhibition of the human Glutaminyl Cyclase
(2017-03-24)The mammalian zinc-dependent enzyme glutaminyl cyclase (QC, EC 2.3.2.5) belongs to the family of transferases and plays a crucial role in hormone maturation by cyclizing irreversibly N-terminal glutamines post-translationally ... -
Modulating the aggregation of alpha-synuclein and prion protein with small molecules.
(2016-11-07)As living and health conditions improve in modern societies, the percentage of older people rises. A byproduct of this ageing is the marked increase of cases of cancer, cardiovascular, and neurodegenerative diseases. Many ... -
Extending the Search Space for Novel Physical Forms of Pharmaceuticals and Biomolecules using High-Pressure Techniques
(2016-06-17)This thesis, which is divided into two parts, describes the use of non-ambient crystallisation techniques, in particular high-pressure, to explore on one hand inclusion complex formation of cyclodextrins with drug molecules ... -
Phosphorylation dependent stability control of the deneddylase DenA and its impact on Aspergillus nidulans development
(2016-04-05)Summary Malfunctioning protein degradation in higher eukaryotes is associated with numerous diseases, including neurodegenerative disorders and cancer. Understanding regulation mechanisms of protein degradation is thus ... -
Deciphering the Catalytic Mechanism of the Zn Enzyme Glutaminyl Cyclase and the Deduction of Transition-State Analog Inhibitors
(2015-07-20)Zn(II)-dependent glutaminyl cyclase (QC) converts N-terminal glutamine or glutamate residues of peptides and proteins. The reaction product is in both cases N-terminal pyroglutamic acid (pyroGlu). In animals the glutaminyl ... -
Characterization of chondrogenic progenitor cells using mass spectrometry and multidimensional separation approaches
(2015-07-03)Modern day mass spectrometry (MS) has evolved into a powerful analytical technique, central to the field of proteomics. Currently, the identification and quantification of proteins from different biological samples can be ... -
Investigations of sirtuin metabolism
(2015-04-15)Sirtuins are a class of histone deacetylases (HDACs) found in all organisms in all three domains of life. Unlike other classes, which hydrolyze water, sirtuins require NAD+ as co-substrate and form nicotinamide and the ... -
Molecular Dynamics Studies of the Phi29 Connector-DNA complex
(2015-04-10)During replication of the Phi29 bacteriophage, a DNA packaging motor packages the viral DNA into the procapsid against a maximum pressure difference of ~60 atm, which is generated by the already packed DNA. Several models ... -
Crystal Structures of a Bacterial Isocitrate Dehydrogenase and the Human Sulfamidase
(2015-01-09)In an X-ray crystallographic experiment, intensities and directions of X-rays scattered by electrons in a crystal are measured. However, the relative phase information in the interference pattern is lost. If we knew the ... -
A method for the genetically encoded incorporation of FRET pairs into proteins
(2014-09-03)Proteins are composed of 20 canonical amino acids whose unique arrangements predefine a protein’s structure and function. Importantly, most proteins are not static conformations but rather very dynamic entities that undergo ... -
Protein interactions along the presequence import pathway
(2014-05-09)In this thesis the mechanisms of protein transport by the translocase of the inner mitochondrial membrane (TIM23) was investigated. Purified presequence peptides containing a p-benzophenyalalanine were established as a ... -
Structural characterization of the minimal human RISC-loading complex
(2014-03-07)Gene expression is the prerequisite for protein biosynthesis in all cells. Rapid and fine-tuned control of gene expression in response to environmental changes is of great importance. A major gene regulation mechanism in ... -
Thermal coefficients of methyl groups within ubiquitin and metabolic coupling of NAA and lactate in cortical neurons
(2013-10-30)Protein folding and molecular recognition are physiological processes that are intricately linked to their dynamic signature and reflected in their thermal coefficients. Additionally, the local conformational entropy is ... -
Elektrophysiologische Charakterisierung des mitochondrialen Porins VDAC1 und des antimikrobiellen Peptids Dermcidin in lösungsmittelfreien Modellmembranen
(2013-07-04)Solvent free lipid bilayers were used for the electrophysiological characterization of the most abundant protein of the outer mitochondrial membrane, the isoform 1 of the voltage dependent anion channel (VDAC1), and the ... -
In vitro studies of protein interactions on substrate supported artificial membranes
(2013-02-12)Protein interactions that take place at the interface of a membrane are abundant within cellular organisms. Hence, surface coupled protein interactions are a matter of ongoing scientific investigation. In this work, elected ...