Browsing Naturwissenschaften, Mathematik und Informatik by Referee "Waack, Stephan Prof. Dr."
Now showing items 21-40 of 58
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Developer-Centric Software Assessment
(2018-06-14)Software systems are becoming more and more widespread in all areas of everyday life. Due to the increasing reliance on such systems, there is a need to keep them operational over longer periods of time under constantly ... -
Development of algorithms and next-generation sequencing data workflows for the analysis of gene regulatory networks
(2017-04-11)Unraveling genetic and epigenetic mechanisms behind various biological processes is possible with Next generation sequencing (NGS) methodologies, with a multitude of tools developed to analyze such data. Nevertheless, ... -
On two Random Models in Data Analysis
(2017-03-02)In this thesis, we study two random models with various applications in data analysis. For our first model, we investigate subspaces spanned by biased random vectors. The underlying random model is motivated by applications ... -
Increasing the robustness of active upper limb prostheses
(2017-02-02)This thesis is based on my work done at the Institute for Neurorehabilitation Systems at the University Medical Center Goettingen. My work has been partially founded by German Ministry for Education and Research (BMBF) via ... -
Interpretable Binary and Multiclass Prediction Models for Insolvencies and Credit Ratings
(2016-06-10)Insolvency prediction and credit rating are challenging tasks used to evaluate the creditworthiness of commercial enterprises based on qualitative and quantitative attributes. One way to approach these tasks is machine ... -
Development and application of ontologies for biological applications
(2016-02-08)In the century of information technology automatic processing of knowledge is evolving to be a crucial challenge. However, it is usually not obvious to extract information from the syntax of texts. Hence, ontologies are ... -
Generic Methods for Adaptive Management of Service Level Agreements in Cloud Computing
(2015-11-27)The adoption of cloud computing to build and deliver application services has been nothing less than phenomenal. Service oriented systems are being built using disparate sources composed of web services, replicable datastores, ... -
Unravelling Drug Resistance Mechanisms in Breast Cancer
(2015-06-22)The intention of this dissertation is to gain deeper insight into mechanisms of drug action on the genomic and proteomic level in HER2-positive breast cancer cell lines with different resistance phenotypes. In the era of ... -
Application of A Novel Triclustering Method in Analyzing Three Dimensional Transcriptomics Data
(2015-06-19)Due to the advancement of microarray technology over the last decade, it is feasible to monitor the gene expression dynamics not only over a set of replicates but also either a set of time points or doses of chemical ... -
Statistical Methods to Enhance Clinical Prediction with High-Dimensional Data and Ordinal Response
(2015-04-08)Advancing technology has enabled us to study the molecular configuration of single cells or whole tissue samples. Molecular biology produces vast amounts of high-dimensional omics data at continually decreasing costs, ... -
Integration of Pathway Data as Prior Knowledge into Methods for Network Reconstruction
(2014-10-23)Hundreds of databases offer vast amounts of literature knowledge about biological signaling networks. However, this knowledge is rarely integrated into current bioinformatic analyzes due to challenges in the programmatic ... -
Localized Proton Magnetic Resonance Spectroscopy of Mouse Brain In Vivo at High Magnetic Field Strength
(2014-10-01)This work describes the implementation and optimization of single-voxel proton magnetic resonance spectroscopy for absolute quantification of regional metabolite concentration in mouse brain in vivo at 9.4 T. Optimized scheme ... -
A Study of VoIP Performance in Anonymous Network - The Onion Routing (Tor)
(2014-06-23)Information technology is developing rapidly, especially in the field of computer science, telecommunications and information systems. In the early days of telecommunications, voice networks could not be combined with data ... -
Development of novel Classical and Quantum Information Theory Based Methods for the Detection of Compensatory Mutations in MSAs
(2014-05-13)Multiple sequence alignments (MSAs) of homologous proteins are useful tools to characterize compensatory mutations between non-conserved residue sites. The identification of these residue sites in MSAs is an important ... -
Social-Based Data Routing Strategies in Delay Tolerant Networks
(2014-04-03)Delay Tolerant networks (DTNs) are intermittently connected mobile networks in which the end-to-end paths do not exist. Data delivery in such networks relies upon the contacts that use "store-carry-and-forward" paradigm ... -
Verification of Security Properties Using Formal Techniques
(2014-02-12)Nowadays, the necessity of developing collaborative and distributed computing systems makes networks, and specially Internet, the key element of the system design process. Several new applications have been appeared in ... -
Detektion und Analyse synergistischer Einflüsse multipler Stimuli auf zelluläre Signaltransduktionsnetzwerke in Säugetieren
(2013-11-21)Simultaneously working signals affect the behavior of organisms at systems level. Different signals have to be integrated and evaluated simultaneously by the cell. Synergistic interactions are one possibility how a cell ... -
Stable Bases for Kernel Based Methods
(2013-03-18)Kernels K arise in many contexts, including approximation, surface reconstruction, numerical analysis of fluid-structure interactions, and geostatistics. In particular, the span of translates K(.,x) for scattered ... -
Graph based fusion of high-dimensional gene- and microRNA expression data
(2013-01-25)One of the main goals in cancer studies including high-throughput microRNA (miRNA) and mRNA data is to find and assess prognostic signatures capable of predicting clinical outcome. Both mRNA and miRNA expression changes ... -
Prediction of Protein-Protein Interaction Sites with Conditional Random Fields
(2012-11-28)Protein-protein interactions appear in almost every biological process. Proteins are mainly folded into three dimensional structures, which requires that a meaningful prediction should take consideration of the important ...