Browsing Naturwissenschaften, Mathematik und Informatik by Title
Now showing items 4652-4671 of 5781
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Structural characterization of alpha-synuclein aggregates seeded by patient material
(2019-12-12)Neurodegenerative diseases share a common underlying pathologic hallmark, the appearance of insoluble protein aggregates in diverse tissues of the nervous system. For many neurodegenerative diseases a common temporal and ... -
Structural characterization of autophagy related protein complexes
(2017-06-08)Autophagy is a conserved and highly regulated process in eukaryotic cells that plays an important role in maintaining cellular homeostasis. During macroautophagy a double membrane grows de novo that encloses cytoplasmic ... -
Structural characterization of human spliceosome activation by cryo-EM
(2022-01-27)Eukaryotic genes are transcribed as precursor mRNA (pre-mRNA), in which coding regions (exons) are interrupted by non-coding regions (introns). Introns are excised and exons are ligated together in a two-step process ... -
Structural characterization of membrane proteins by solid-state NMR spectroscopy
(2008-07-25)In this work, nuclear magnetic resonance spectroscopy was employed to characterize the three-dimensional atomic structure of proteins and other biomolecules in the solid phase. A method for ... -
Structural characterization of the lysosomal 66.3 kDa protein and of the DNA repair enzyme Mth0212 by means of X-ray crystallography
(2009-06-17)This PhD thesis is divided into two parts both dealing with structural characterization of macromolecules by means of X-ray crystallography. Part I concerns the lysosomal 66.3 kDa protein ... -
Structural characterization of the minimal human RISC-loading complex
(2014-03-07)Gene expression is the prerequisite for protein biosynthesis in all cells. Rapid and fine-tuned control of gene expression in response to environmental changes is of great importance. A major gene regulation mechanism in ... -
Structural characterization of the two copper proteins nitrous oxide reductase from Pseudomonas stutzeri and laccase Lcc5 from Coprinopsis cinerea
(2011-08-24)Although, the reduction of nitrous oxide (N2O) is highly exergonic, a high activation barrier hinders a spontaneous reaction. With regard to inertness, N2O is second only to molecular ... -
Structural control on fluid migration in inverted sedimentary basins
(2019-04-30)Analogue studies in earth sciences are crucial for the understanding of various geological environments that may serve as future storage sites for carbon dioxide captured at an industrial scale. The feasibility of CCS pilot ... -
Structural finger-jointing of European beech and birch – Studies on the joining and bonding mechanisms
(2025-08-18)In the past, the finger-jointing of hardwoods was less researched and standardised compared to softwoods. This is associated with a lack of knowledge and uncertainties in the production of load-bearing hardwood engineered ... -
Structural studies of short nucleosome arrays containing linker histone H1
(2022-04-21)The DNA inside the eukaryotic nucleus is bound by octamers of histone proteins to form the nucleosome as the basic repeating unit of chromatin. Along the genome, nucleosomes locally form regularly spaced arrays. The relative ... -
Structural, magnetic and electrical transport properties of GaN-based magnetic semiconductors and hybrid structures
(2011-05-24)Semiconductors, materials in which the charge transport can be well controlled, are at present invaluable ingredients in the emerging field of information technology. The elemental modules ... -
Structural/functional analysis of synaptotagmin 1 in synaptic transmission using hippocampal autapses
(2005-06-10)Synaptotagmin 1 is a presynaptic vesicular protein, which has been implicated as a putative Ca2+ sensor for fast neurotransmitter release in central nervous system. Structurally, it ... -
Structure Analysis of the Pohlmeyer-Rehren Lie Algebra and Adaptations of the Hall Algorithm to Non-Free Graded Lie Algebras
(2021-06-14)The Pohlmeyer-Rehren Lie algebra $\mathfrak{g}$ is an infinite-dimensional $\mathbb{Z}$-graded Lie algebra that was discovered in the context of string quantization in $d$-dimensional spacetime by K. Pohlmeyer and his ... -
Structure and diversity of cloud forest bird communities in Alta Verapaz, Guatemala, and implications for conservation.
(2003-12-10)In a 102 ha study plot in the Sierra Yalijux, Alta Verapaz, Guatemala (90° 03 W, 15° 22 N, 1980 2550 m) the bird community was observed with standardized mark-recapture and transect ... -
Structure and diversity of the dry woodland savanna of northern Namibia
(2005-03-18)The dry woodland savannas are of significant importance for the regional economy as they provide the resources including food, building material and fuel. The factors that affect ... -
Structure and Dynamics of Discussions on the Social Media Platform Reddit
(2024-05-28)The last fifteen years have witnessed a tremendous rise in the impact of online social media on our lives. Platforms such as Facebook, Twitter, YouTube, and Reddit have radically changed the way we communicate and consume ... -
Structure and Dynamics of Molecular-Dynamics Simulated Undercooled Ni-Zr-Al Melts
(2001-08-30)Molecular dynamics (MD) simulations are used in this work to model the massive-metallic-glass forming Ni25Zr60Al15 alloy. The applied atomic interaction model predicts radial distribution functions for the glass that ... -
Structure and Dynamics of Plumbing Systems of Oceanic Shield Volcanoes: An Example from Réunion Island
(2008-07-10)This study focuses on the volcano-tectonic evolution of the two main volcanoes that constitute Réunion Island. This island, located in the south-western part of the Indian Ocean, hosts two ... -
Structure and dynamics of the aggregation mechanism of the Parkinson´s disease-associated protein alpha-synuclein
(2006-09-18)In Parkinson s disease (PD), intracellular neuronal inclusions containing amyloid-like aggregates of the protein alpha-synuclein (aS) are deposited in the pigmented nuclei of the brainstem. ... -
Structure and Evolution of Visual Cortical Representations
(2025-05-28)Fully understanding the functions and mechanisms of the complex machinery that is our brain requires advanced statistical data analysis and theoretical modelling. In this thesis, I develop and apply statistical tools and ...