Browsing Naturwissenschaften, Mathematik und Informatik by Advisor "Figura, Kurt von Prof. Dr. Dr. h.c."
Now showing items 1-10 of 10
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Proteomanalyse lysosomaler Membranen: Identifizierung und Charakterisierung neuer lysosomaler Membranproteine
(2009-06-18)Lysosomes are intracellullar acidic vesicles, which contain a variety of soluble and membrane-bound proteins like hydrolases and transport-systems. They are found in all nucleated ... -
A novel pathway for VLDL assembly in the mouse liver
(2006-12-11)LDL is thought to be endocytosed and completely degraded by peripheral cells and the liver. Using primary mouse hepatocytes, mouse liver perfusion and intravenous LDL-injection in mice, it ... -
Efficacy of enzyme replacement therapy in α-manosidosis mice
(2006-08-11)The Lysosomal Storage Disorders (LSD) are a group of about 50 diseases caused by genetic defects that affect one or more of the lysosomal hydrolases. The defect results in the accumulation ... -
Biochemical and cell biological analysis of the mechanism of RNA interference in human cells
(2006-04-10)RNA interference (RNAi) in human cells is efficiently triggered by short interfering RNA (siRNA) duplexes of 19-24 base-pairs (bp), which mimic the double-stranded processing intermediates ... -
Molecular Characterization of pFGE, the Paralog of the C-α-Formylglycine-generating Enzyme
(2006-03-01)C-α formylglycine (FGly) is the catalytic residue in the active site of sulfatases. In eukaryotes, it is generated in the endoplasmic reticulum by post-translational modification of a ... -
Recognition of basic sorting motifs within synaptic membrane cargo proteins by the clathrin-adaptor complex AP-2
(2005-08-24)Communication in the central nervous system (CNS) occurs via chemical synapses, intercellular asymmetric junctions between an axon and the dendrite of a neighbouring neuron. Synapses comprised ... -
Post-translational generation of Cá-formylglycine in Prokaryotic Sulfatsases by Radical SAM-Proteins
(2004-02-16)Cá-formylglycine is the catalytic residue of sulfatases. FGly is generated by posttranslational modification of a cysteine (pro- and eukaryotes) or serine (prokaryotes) located in a conserved ... -
Identifizierung der für die Agonisten-induzierte Phosphorylierung und Internalisierung relevanten Serine und Threonine in der C-terminalen Domäne des humanen Prostaglandin E2 Rezeptors, Subtyp EP4
(2003-08-18)The prostanoid receptors belong to the family of G protein-coupled receptors with seven transmembrane domains. Four different subtypes have been identified for prostaglandin E2 (PGE2). The ... -
Congenital Disorder of Glycosylation (CDG) - Ih
(2003-04-17)Die "Congenital Disorders of Glycosylation (CDG)" beschreiben eine schnell wachsende Gruppe von multisystemischen Erberkrankungen, die durch Mutationen in für die Biosynthese von Glykoproteinen ... -
Insulin-Like Growth Factor Binding Protein-6: Posttranslational modifications and sorting in polarized MDCK cells
(2002-07-02)The insulin-like growth factors (IGFs) promote proliferation, and differentiation of a variety of cell types. The IGF availability and interactions with specific cell surface IGF-receptors ...