Browsing Naturwissenschaften, Mathematik und Informatik by Advisor "Jahn, Reinhard Prof. Dr."
Now showing items 1-15 of 15
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Global Analysis of Protein Phosphorylation Regulation upon Stimulation of Exocytosis in the Nerve Terminal
(2017-06-14)In chemical synapses, neurons communicate with each other via two mechanisms known as fast and slow synaptic transmission. Fast synaptic transmission happens within milliseconds and is triggered by the arrival of an action ... -
Transport Mechanisms of the Vesicular Glutamate Transporter 1
(2013-05-08)In neuronal signal transmission, vesicular neurotransmitter transporters play a key role in quantal size modification. They are filling synaptic vesicles (SVs) with neurotransmitter, fuelled by an electrochemical gradient ... -
Isolation and characterisation of synaptic vesicles from mouse brain
(2011-08-08)All eukaryotic cells exhibit a constant turnover of membrane components via trafficking of vesicles between subcellular compartments. A classical example of a dynamic membrane delimited ... -
On the chloride dependence of vesicular glutamate transport
(2010-06-10)Neurons release neurotransmitters in discrete amounts, the quanta. The transmitters are stored in small membrane-bound organelles, the synaptic vesicles, in the vicinity of the plasma ... -
Investigation of early endosomal sorting and budding
(2009-11-04)Early endosomes constitute a major sorting platform of eukaryotic cells. They receive endocytic carrier vesicles from the plasma membrane and trafficking vesicles from the Golgi complex and ... -
Eine funktionelle Charakterisierung der frühendosomalen SNARE-Proteine
(2009-06-19)Most intracellular transport processes occur via budding and fusion of vesicles, where fusion is dependent on SNARE proteins. Fusion is preceded by docking, the close contact of vesicles ... -
Biophysikalische und thermodynamische Charakterisierung der neuronalen SNARE-Komplexbildung
(2008-07-16)Membrane fusion events are mediated by a set of conserved protein machinery, the SNARE proteins. SNARE proteins assemble into a very stable α-helical complex between two membranes. The ... -
Characterization of Synaptotagmin Function In Calcium Dependent Neuronal Exocytosis
(2007-08-17)Synaptotagmin 1 is a synaptic vesicle protein believed to be the calcium sensor at the neuronal synapse. The protein consists of two calcium dependent membrane binding domains known as the ... -
Der Syntaxin 1-Cluster - Organisation und Dynamik einer supramolekularen Struktur der Plasmamembran
(2007-06-27)The plasma membrane of a eukaryotic cell shows much more lateral heterogeneity as would be expected according to the fluid mosaic model proposed by Singer and Nicolson in 1972. Many proteins ... -
Fluoreszenzmikroskopische Studien an Plasmamembranen zur Untersuchung der molekularen Mechanismen der neuronalen Exocytose
(2006-09-18)During regulated exocytosis from neurons and neuroendocrine cells a rise in intracellular calcium concentration leads to the formation of the so-called core-complex, between the plasmalemmal ... -
Fluoreszenzmikroskopische Studien an Plasmamembranen zur Untersuchung der molekularen Mechanismen der neuronalen Exocytose
(2006-09-18)During regulated exocytosis from neurons and neuroendocrine cells a rise in intracellular calcium concentration leads to the formation of the so-called core-complex, between the plasmalemmal ... -
SNARE assembly and regulation on membranes
(2006-08-01)The fusion of synaptic vesicles with the pre-synaptic plasma membrane is mediated by SNARE proteins. This work provides key insights into the behaviour of synaptobrevin, the SNARE protein ... -
Characterisation of the Early Endosomal SNARE Complex
(2005-11-23)SNARE proteins are crucial factors in membrane fusion. These membrane proteins assemble to four-helix coiled-coils consisting of four SNARE helices: Qa, Qb, Qc and R, thereby fusing opposing ... -
The establishment and characterization of an improved cell-free assay for exocytosis in neuroendocrine PC12 cells
(2005-11-04)Regulated exocytosis in neurons and neuroendocrine cells is mediated by the SNARE proteins synaptobrevin/VAMP, SNAP-25, and syntaxin 1. During fusion, these SNAREs form a stable complex ... -
Studien zu den biochemischen und strukturellen Eigenschaften von Snapin und zu seiner Rolle in der neuronalen Exozytose
(2005-01-10)Snapin has been originally described by Ilardi et al., 1999 as a brain specific protein that interacts with SNAP-25, one of the central proteins in neuronal exocytosis. Biochemical data on ...