Browsing Naturwissenschaften, Mathematik und Informatik by Advisor "Neher, Erwin Prof. Dr."
Now showing items 1-14 of 14
-
Study of synaptic vesicle cycling during exo- and endocytosis using optical approaches
(2012-09-25)In the central nervous system, communication between nerve cells mainly occurs at synapses via chemical neurotransmitters. Upon stimulation the transmitters are released by Ca2+-triggered exocytosis of synaptic vesicles ... -
Epac-mediated modulation of neurotransmitter release from cultured hippocampal neurons
(2008-07-15)cAMP regulates secretory processes through both protein kinase A (PKA)-independent and PKA-dependent signaling pathways. However, their relative contributions to fast neurotransmission are ... -
Stimulus-secretion coupling in pancreatic β-cells of healthy and diabetic rats in tissue slice preparation
(2006-07-04)A primary event in the development of type 2 diabetes is a decrease in the capacity of pancreatic β-cells to secrete insulin in response to glucose stimulation. The Goto Kakizaki (GK) ... -
Spatial and temporal aspects of PI(4,5)P<sub>2</sub> and SNAREs in exocytosis studied using isolated membrane sheets and capacitance measurements
(2006-02-09)Ca2+-triggered exocytosis is a highly regulated process and the proteinaceous machinery mediating and regulating it has been studied in detail over the last decade. However, the participation ... -
Probing vesicle dynamics within small synapses
(2006-01-27)Sustained synaptic transmission at the hippocampal synapse (Ø∼1 μm) requires continuous exocytosis and subsequent endocytosis of synaptic vesicles (Ø∼35 nm). The kinetics of this process ... -
Analysis of two kinetically distinct components of transmitter release at a fast synapse of the mammalian central nervous system
(2006-01-06)Two kinetically distinct components of transmitter release have been observed in Ca2+ uncaging experiments at a CNS synapse in rats, and both release components showed a steep dependence ... -
Munc18 function in large dense-core vesicle exocytosis
(2005-03-23)Neurotransmitter and hormon release is based on Ca2+ dependent exocytosis. The sequential steps of exocytosis are executed by proteins and protein complexes. Formation of the SNARE complex ... -
The Regulatory Role of Syntaxin 1 N-terminal Conformation in Vesicle Priming and Exocytosis
(2004-12-16)During vesicle priming at the central synapse, Syntaxin 1, together with SNAP25 and Synaptobrevin, assemble into the synaptic SNARE complex. The formation of SNARE complex is thought to ... -
Molecular dynamics of clathrin proteins at endocytic sites studied with evanescent-wave microscopy
(2004-10-04)Clathrin (consisting of a light chain and a heavy chain subunit) is a triskelion-shaped molecule that self-assembles into polyhedral lattices on cellular membranes. It has a pivotal role ... -
Investigation of Interactions between Homeodomain Proteins and DNA
(2004-09-10)In this work spectroscopic and transient-kinetic methods were applied to investigate homeodomain-DNA interactions. The analysis of intrinsic fluorescence and circular dichroism spectra of ... -
Charakterisierung von einer retrograden Modulation inhibitorischer synaptischer Transmission im Kleinhirn der Ratte
(2003-12-15)In recent years, a lot of interest has been given to retrograde modulatory mechanisms of synaptic transmission: in many regions of the central nervous system, substances released from ... -
Anwendung der Fluoreszenz-Korrelations-Spektroskopie zur Untersuchung dynamischer Prozesse in lebenden Zellen
(2001-05-09)In this thesis the Fluorescence Correlation Spectroscopy (FCS) technique is applied to cell-physiologically relevant reaction and diffusion problems in living cells. In the nucleus as well ... -
Statistical analysis of synaptic transmission at the calyx of Held synapse
(2001-04-25)In order to distinguish pre- and postsynaptic mechanisms contributing to short-term synaptic depression at the calyx of Held synapse in the rat auditory pathway, non-stationary EPSC fluctuation ...