Browsing Naturwissenschaften, Mathematik und Informatik by Advisor "Pieler, Tomas Prof. Dr."
Now showing items 1-15 of 15
-
Expression screen for Wnt signaling-like phenotypes identifies Fam132b as a novel inhibitor of BMP signaling in Xenopus
(2014-03-13)The canonical Wnt signaling pathway is known to regulate multiple developmental events,including development of the digestive tract. In this study, we wanted to systematically analyze the role of the Wnt/β-Catenin signaling ... -
Identifikation von Zielen und molekulare Charakterisierung des RNA-Bindeproteins XSeb4R in Xenopus laevis
(2009-10-28)While developmental processes have been extensively studied in the context of transcriptional regulation, much less is known about regulation via translational regulation. RNA-binding ... -
Die Regulation der Pankreasentwicklung von Xenopus laevis durch Transkriptionsfaktornetzwerke
(2008-12-05)Pancreas development is under control of signalling pathways and a complex transcription factor network. It was previously reported that in Xenopus laevis retinoic acid (RA)- signalling was ... -
Identification and Functional Characterization of Trans-acting Factors Involved in Vegetal mRNA Localization in Xenopus Oocytes
(2008-07-24)Directional transport of specific mRNAs is a mechanism for the generation of asymmetry which is of primary biological importance. In Xenopus oocytes, mRNA localization to the vegetal ... -
Identifizierung und funktionelle Charakterisierung neuer RNA-Transportfaktoren in der Xenopus laevis Oozyte
(2008-06-05)RNA localization is an important strategy to create intracellular asymmetry and plays an essential role in early embryogenesis in several organisms. Revealing the molecular mechanism of ... -
Die Funktion des Wnt Antagonisten XsFRP5 während der frühembryonalen Musterbildung des Entoderms in Xenopus laevis
(2008-05-08)In vertebrates the embryonic development of all endodermal organs follows conserved molecular mechanisms. Wnt signaling is supposed to play a key role during these processes. The gastrointestinal tract comprises the ... -
Regulation der Neurogenese durch bHLH-O-Proteine in Xenopus laevis
(2006-12-11)Transcriptional activators and repressors of the bHLH protein family are involved in multiple developmental processes, including the formation of the nervous system in vertebrates and ... -
Regulation of pancreas development in <i>Xenopus laevis</i>
(2006-07-25)How and when the vertebrate endoderm is first subdivided into discrete progenitor cell populations that will give rise to the different major organs, including pancreas and liver, is only ... -
Pancreas Development in <i>Xenopus laevis</i>
(2006-01-02)Previous studies on pancreas development have mainly relied on the use of mouse as a model system in gene targeting experiments. In this study, Xenopus laevis is employed for the analysis ... -
Identifizierung neuer vegetal lokalisierter RNAs in der Xenopus laevis Oozyte und deren funktionelle Charakterisierung
(2005-12-16)Vegetally localized mRNA molecules in Xenopus laevis oocytes play important roles in the formation of the primary germ layers and the germ line. In order to identify novel vegetally localized ... -
Identifikation und funktionelle Analyse von Xdach1 und Xeya3 als morphogenetische Faktoren der Kopfentwicklung von Xenopus laevis
(2005-02-14)Dachshund (dac) and Eyes absent (eya) are two transcription factors indispensable for proper compound eye development in Drosophila melanogaster. In vertebrates homologues of dac and eya ... -
Größenegulation der Augenanlage von Xenopus laevis durch Inhibition von Hedgehog-, Fgf- und Wnt-Signalen
(2004-01-16)The molecular mechanisms, which underlie the control of organ size during embryogenesis, are only poorly understood. Using the South African clawed frog Xenopus laevis as a ... -
Analyse der differentiellen Expression von Transportfaktoren und deren Funktion bei dem nukleocytoplasmatischen Transport von TFIIIA
(2002-11-21)In this thesis the nuclear localisation signal (NLS) of the transcription factor IIIA (TFIIIA) was localized within the zinc fingers 3, 4 and 7 to 9. The transport mediating regions are ... -
Identification and Functional Characterization of Novel Genes Involved in Primary Neurogenesis in Xenopus laevis
(2002-07-16)The South African claw-toed frog, Xenopus laevis, is a good model to study neurogenesis in vertebrates. Early on, at the open neural plate stage, the territory of primary neurons is nicely ... -
Ueber die Funktion von Zinkfinger Proteinen bei der Induktion des Mesoderms in Xenopus laevis
(2001-12-10)Mesoderm induction and dorsal-ventral patterning in vertebrates and invertebrates involves signalli ng by members of the transforming growth factor-beta (TGF-beta) superfamily cytokines. ...