Browsing Naturwissenschaften, Mathematik und Informatik by Advisor "Stark, Holger Prof. Dr."
Now showing items 1-5 of 5
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Neural Network Based Methods for the Conformational Landscape Determination in High Resolution Cryo-Electron Microscopy
(2022-09-22)During the last decades 3D transmission electron cryo-microscopy (cryoEM) has emerged to be the method of choice for the study of motion in larger protein complexes. The aim of Single Particle Analysis (SPA) in cryoEM is ... -
Improving electron microscopic hardware to push the resolution limits in single particle cryo-EM
(2022-07-19)Electron cryomicroscopy (cryo-EM) is a powerful tool in structural biology for determining 3D structures of macromolecular complexes. In the previous decade, many technological advancements have been introduced to improve ... -
Manipulating the Conformational Landscape of Large Macromolecular Complexes
(2022-04-08)The de novo synthesis of fatty acids is one of the most central metabolic pathways in all forms of life. Among all known organisms, fatty acids are highly essential. Besides their role as energy resource, they are also ... -
Structural characterization of human spliceosome activation by cryo-EM
(2022-01-27)Eukaryotic genes are transcribed as precursor mRNA (pre-mRNA), in which coding regions (exons) are interrupted by non-coding regions (introns). Introns are excised and exons are ligated together in a two-step process ... -
Towards validation and map quality assessment in electron cryo-microscopy
(2020-09-10)Structural biology is the study of the assembly of proteins and protein complexes. These proteins and protein complexes are small units in the cell of a living being. In order to sustain life they take care of biochemical ...