Browsing Naturwissenschaften, Mathematik und Informatik by Advisor "Zweckstetter, Markus Prof. Dr."
Now showing items 1-11 of 11
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NMR spectroscopy of liquid-liquid phase separation related to transcription
(2024-06-05)The Carboxyl-Terminal Domain (CTD) of the largest subunit RPB1 of RNA Polymerase II (Pol II), is a disordered low-complexity region which is crucial for pre-mRNA transcription and processing. Due to its highly repetitive, ... -
NMR Spectroscopy of Biomolecular Liquid-Liquid Phase Separation
(2024-02-09)Phase separation of biomolecules has transformed our understanding of cell organization and function, motivating intensive research in the last decade. New evidence for their critical role in mechanisms essential for ... -
Investigation of the role of prolyl isomerase A in protein misfolding associated with neurodegenerative diseases
(2023-06-26)Misfolded proteins and disrupted homeostasis are key characteristics of neurodegenerative diseases. There is a strong association between intrinsically disordered proteins and pathogenic misfolding in neurodegenerative ... -
Investigation on the molecular factors driving the formation of distinct tau 'strains'
(2022-11-28)Pathological aggregation of the microtubule-binding protein tau into amyloid fibrils is a hallmark of different neurodegenerative diseases collectively termed tauopathies. To date, tau amyloid structures associated with ... -
Investigation on the Physiological and Pathological Aspects of the Proline-Rich Region of the Microtubule-Associated Protein Tau
(2020-12-17)The microtubule-associated protein tau is involved in several neurodegenerative diseases including Alzheimer’s disease (AD), Pick’s disease (PiD), Progressive Supranuclear Palsy (PSP) and others. The aggregation and ... -
Structural characterization of alpha-synuclein aggregates seeded by patient material
(2019-12-12)Neurodegenerative diseases share a common underlying pathologic hallmark, the appearance of insoluble protein aggregates in diverse tissues of the nervous system. For many neurodegenerative diseases a common temporal and ... -
Modulating the aggregation of alpha-synuclein and prion protein with small molecules.
(2016-11-07)As living and health conditions improve in modern societies, the percentage of older people rises. A byproduct of this ageing is the marked increase of cases of cancer, cardiovascular, and neurodegenerative diseases. Many ... -
Dynamics and interactions of the voltage-dependent anion channel 1 studied by NMR spectroscopy
(2012-06-20)The voltage-dependent anion channel (VDAC), the most abundant protein in the outer mitochondrial membrane, acts as a gatekeeper for the entry and exit of mitochondrial metabolites and is involved in mitochondrial apoptosis. ... -
Unraveling the structure of monomeric and fibrilized 441-residue tau with NMR spectroscopy
(2011-09-14)The microtubule-associated, intrinsically disordered protein tau is a key- protein in maintaining the axonal transport in neurons. The association to and the dissociation from microtubules is regulated via a complex ... -
High-resolution characterization of structural changes involved in prion diseases and dialysis-related amyloidosis
(2009-10-16)Protein aggregation is the cause of several human diseases such as diabetes mellitus type 2, Parkinson s disease, Alzheimer s disease, Huntington s disease, spongiform encephalopathies, ... -
Characterization of the amyloid precursor of alpha-synuclein by NMR spectroscopy
(2008-11-04)A number of human neurodegenerative diseases, including Alzheimer"s and Parkinson"s diseases (PD), are associated with the deposition of proteinaceous aggregates known as amyloid fibrils. ...