Browsing Naturwissenschaften, Mathematik und Informatik by Referee "Brück, Wolfgang Prof. Dr."
Now showing items 1-7 of 7
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The Integration of the Brain Bank Imaging Workflow into the Infrastructure of the Multiple Sclerosis Research Network
(2019-03-26)Digital pathology (DP) provides powerful tools for the acquisition, management, storage, viewing, and analysis of high-resolution digital microscope images. During the last decade, DP tools were increasingly used for a ... -
Ryanodine receptors in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis
(2015-10-19)The activation of auto-aggressive T cells is crucial for the development of autoimmune diseases, such as multiple sclerosis (MS) or its animal model experimental autoimmune encephalomyelitis (EAE). T cell activation relies ... -
The Role of the p75 Neurotrophin Receptor in Experimental Inflammation of the Central Nervous System
(2011-05-04)The extent of the permanent clinical disability in multiple sclerosis patients emerges from axonal damage and loss. In this study, we show a major role of the low affinity neurotrophin ... -
Genomweite Suche neuer Modulatoren der Signaltransduktion in kardialer Hypertrophie und Herzinsuffizienz
(2011-02-23)Activated through cytokines, growth factors and hormones the MAPK signaling pathway regulates cell response to environmental cues. The signaling cascade is involved in fundamental cellular ... -
Der Einfluss mechanischer Last auf das Potential multipotenter adulter Keimbahnstammzellen zur kardialen Regeneration
(2011-02-23)In the present thesis murine multipotent adult germline stem cells (maGSCs) were analysed under different conditions in vivo and in vitro. It was shown in vivo that undifferentiated maGSCs ... -
Tyrphostin AG126 modulates Toll-like receptor (TLR) activation-induced functions in microglia by protein tyrosine kinase (PTK) -dependent and -independent mechanisms
(2010-10-25)Tyrphostins comprise a class of synthetic protein tyrosine kinase (PTK) inhibitors structurally derived from tyrosine and aimed at the specific prevention of substrate phosphorylation. The ... -
The Diversity of TLR4-triggered Responses in Mouse Microglia
(2010-10-08)Microglia are the major immunocompetent effector cells of the CNS. Steadily monitoring their neighborhood they are always ready to transform to activated states upon encounters with ...