Browsing Naturwissenschaften, Mathematik und Informatik by Referee "Brockmöller, Jürgen Prof. Dr."
Now showing items 1-9 of 9
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Establishment of human lymphoma cell lines with different thiopurine S-methyltransferase (TPMT) activities and differential proteome analysis after thiopurine exposure.
(2013-04-09)Thiopurines are purine analogues used as immunosuppressive and antileukemic agents. Thiopurine activation requires extensive metabolism that involves many enzymatic reactions and TPMT is one of the crucial enzymes in the ... -
OCT1-mediated cellular drug uptake and interactions between drug transport and drug metabolism
(2012-12-07)OCT1 is a polyspecific organic cation transporter belonging to the solute carrier gene family SLC22. Human OCT1 is mainly expressed on the sinusoidal membrane of hepatocytes and thus may play an important role in ... -
Calreticulin in kidney function and disease: chronic low level of calreticulin impairs Ca2+ homeostasis leading to mitochondrial dysfunction and chronic renal injury
(2012-11-28)Chronic kidney disease (CKD) is becoming a major public health problem worldwide. The persistent progression of CKD is postulated to result from a self-perpetuating vicious cycle of events activated after initial injury. ... -
Identification of interacting partners of mammalian target of rapamycin complex 1 (mTORC1) assembly in human lymphocytes
(2012-02-14)The mammalian target of rapamycin (mTOR) is an intracellular protein kinase that plays a key role in the control of cell growth, differentiation, cell survival, and cell proliferation. In ... -
Charakterisierung des 5-HT<sub>3B</sub>-Promotors der Ratte vor dem Hintergrund eines mit Chemotherapie-induziertem Erbrechen assoziierten Polymorphismus
(2012-01-24)5-HT3B is a subunit of the serotonin receptor type 3 (5-HT3), which is an ion channel of the cys-loop receptor family. The gene HTR3B encodes for 5-HT3B. The polymorphism ... -
Expression von SLC-Transportern in Melanomzelllinien und Charakterisierung von MATE1 und OCT1 in ihrer Funktion als Zytostatikatransporter
(2011-11-24)A challenging problem of current chemotherapy is the low response to antineoplastic agents. Partially, this kind of chemoresistance is based on a low accumulation of these agents in tumour ... -
Identifikation von Mutationen im Tumorsuppressorgen p53 und des Bakteriums Helicobacter pylori in Magenkarzinomen histopathologischer Präparate aus verschiedenen medizinhistorischen Sammlungen
(2011-05-25)Cancer results in complex changes and events. An important key element in the initiation is the interaction between genotype and environment. In gastric cancer, the incidence has steadily ... -
Einfluss der Immunsuppressiva Cyclosporin A und Everolimus auf die funktionelle DNA-Reparaturfähigkeit sowie auf die Regulation von DNA-Reparatur-Genen
(2009-11-25)Unlike other immunosuppressive drugs including Everolimus, Cyclosporin A causes a dramatic increase of UV-induced skin cancer in transplant patients. The molecular mechanisms of Cyclosporin ... -
Gesangskontrolle durch Neurone des Zentralkomplexes: Physiologische und immunzytochemische Untersuchungen an primären Zellkulturen aus dem Feldheuschreckengehirn
(2008-08-20)Acridid grasshoppers communicate with specific song patterns in the context of attracting partners for reproduction, courting and agonistic behavior. When to sing and which song pattern ...