Browsing Naturwissenschaften, Mathematik und Informatik by Referee "Brose, Nils Prof. Dr."
Now showing items 1-20 of 39
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Characterization of Synaptic Transmission Abnormalities in Neurological Disorders of the Presynaptic Terminal
(2022-03-04)Seminal methodological advancements in the field of human genetics now allow for low-cost sequencing of complete coding genomes, and rich sources of corresponding data now exist for healthy and patient cohorts, allowing ... -
Characterizing the SUMOylation of APC4 and the Function of APC4 Within Neurons
(2021-09-23)The Anaphase Promoting Complex (APC/C) is an E3 ubiquitin ligase that is involved in multiple molecular processes in eukaryotic cells. It is regulated by an intricate system of post-translational modifications that enables ... -
Resolving the Ultrastructural Organization of Synaptic Vesicle Pools at Hippocampal Mossy Fiber and Schaffer Collateral Synapses
(2021-02-18)The synapse is the functional unit of chemical communication between neurons in the brain. In order to relay information with spatiotemporal precision, the presynaptic compartment utilizes a specialized molecular machinery ... -
Role of chromatin remodelling BAF complex in fate regulation of ventral neural stem cells in the developing telencephalon
(2021-01-14)A role for the multi-subunit BAF (mammalian SWI/SNF) complex in brain development has been postulated as its dysfunction causes several neurological diseases, including intellectual disability, schizophrenia, autism spectrum ... -
Effects of anle138b treatment on amyloid-β neurotoxicity
(2020-10-02)Alzheimer’s disease (AD), the leading etiology of dementia and the fifth cause of death worldwide, has been declared a public health priority by the World Health Organization in 2017. AD is incurable and no treatment can ... -
Mechanisms underlying the functions of sleep in aging during starvation in Caenorhabditis elegans
(2019-09-12)Abstract: Sleep is vital for living organisms. Disruption of sleep is a hallmark of natural aging. A growing body of evidence suggests that sleep serves roles in nervous system-specific functions as well as general cell ... -
Charakterisierung der Aktivität und Inhibition des rekombinanten, spannungsgesteuerten Protonenkanals HV1: Funktionelle Rekonstitution in unilamellare Vesikel
(2018-10-15)The human voltage-gated proton channel (hHV1) regulates important physiological processes like the respiratory burst activity of white blood cells and the motility of spermatozoa by efflux of protons. Reconstitution of the ... -
The presynaptic protein Mover buffers synaptic plasticity at the hippocampal mossy fiber synapse
(2018-03-12)The increase in the complexity of brains in evolution is accompanied by a surprisingly small number of new synaptic proteins, in particular when considering the remarkably wider range of behavioral responses a primate shows ... -
Analysis of protein SUMOylation and its role in Alzheimer's disease using mouse models
(2017-04-26)Post-translational modifications serve as a cellular mechanism for the regulation of the activity, stability and localization of proteins. SUMOylation is a dynamic and reversible post-translational modification, which ... -
A neuronal PIP3-dependent program of oligodendrocyte precursor recruitment and myelination
(2017-01-26)Evolution of myelin has enabled rapid impulse propagation and development of complex brain circuitry. However, the in vivo mechanisms that trigger and orchestrate proliferation of oligodendrocyte precursor cells (OPCs), ... -
Dynamic expression of Mover in rodent endbulbs of Held
(2016-05-12)The central auditory pathway contains highly specialized giant presynaptic nerve terminals specialized to preserve temporal information carried by acoustic signals (Oertel et al., 1999). One of them, the endbulbs of Held, ... -
Analysis of Myelin Membrane Growth in Oligodendrocytes
(2015-12-07)Nervous systems of mammalian organisms are composed of various cell types with different morphology, function and connectivity. Understanding this complicity from a molecular point of view requires the application of ... -
Glutamate receptors potentiate single K-ATP channels through intracellular ATP changes
(2013-12-20)Rett Syndrome (RTT) is a neurodevelopmental disorder caused primarily by mutations in a Mecp2 gene and exclusively affects females. RTT is one of the prevalent developmental disorders with a high frequency of occurrence ... -
The Role of the E3 Ubiquitin Ligases Nedd4-1 and Nedd4-2 in Synaptic Transmission and Plasticity
(2013-05-28)Neurons are highly specialized cells that are connected at synapses to allow for the transfer of neuronal information. The development of synapses and the information processing and memory storage in mature synapses require ... -
Myokardinfarktregeneration unter Verwendung kardiovaskulärer Vorläuferzellen aus murinen und humanen pluripotenten Stammzellen
(2013-02-19)Stem cells hold a great promise in regenerative therapies for cardiovascular diseases. Heart regeneration with stem cells requires a delicate balance between the loss of donor cell pluripotency (so that teratoma formation ... -
Role of myelin-associated NAD+- dependent deacetylase Sirtuin 2 in modifying axonal degeneration
(2013-01-25)In the central nervous system (CNS), oligodendrocytes (OLs) ensheath axons with lipid-rich myelin membranes that provide an electrical insulation and are essential for fast nerve impulse transmission. However, myelination ... -
Conformational state of monomeric kinesin UNC-104
(2012-11-06)The fast anterograde monomeric kinesin-3 motor UNC-104 is crucial for synaptic vesicle transport in neurons. in vitro, UNC-104 is a non-processive motor with biased-diffusional motion behaviour on a single molecule level. ... -
Serum Lipocalin-2 (LCN-2) as a major acute phase protein under different pathological conditions in vivo and in vitro studies
(2012-02-28)Lipocalin-2 (LCN-2) is a pleiotropic 25-kDa secretory protein, currently used as a biomarker for renal injury and inflammation. Its serum level is increased under different pathological ... -
Profiling the inherent vulnerability of motor neuron subtypes
(2012-01-05)Motor neuron diseases (MNDs) are a heterogeneous group of disorders that result in selective degeneration of upper and/or lower motor neurons (MNs). The precise causes of most MNDs remain ... -
Cellular Prion Protein (PrPC): Identification and Characterization of Novel Interacting Partners
(2011-12-07)The cellular prion protein (PrPC) is highly conserved throughout the evolution of mammals. (What does this sentence mean? What do you mean by ``conserved´´? This protein was higly conserved ...