Browsing Naturwissenschaften, Mathematik und Informatik by Referee "Günesdogan, Ufuk Dr."
Now showing items 1-9 of 9
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Computational analysis of nucleosome assembly and cis-regulatory DNA elements
(2025-11-12)Induced pluripotent stem cells (iPSCs) represent embryonic stem cells (ESCs) that are reprogrammed from somatic stem cells. iPSCs can be directed to differentiate into any cell type in the human body, therefore, holding ... -
Studies on Testicular Development and Aging in the Common Marmoset (Callithrix jacchus) and the Establishment of Somatic Testicular Cell Lines
(2025-10-15)The phenomenon of reproductive ageing in women has been known for a long time and some aspects of this phenomenon are well understood. However, ageing effects in the testes were not recognized for a long time, as aged males ... -
Multi-omics analysis of human transcription elongation factors
(2025-08-19)Transcription by RNA Polymerases (Pol) is a highly regulated fundamental process in all living organisms, with its misregulation linked to various diseases, developmental issues, and aging. This intricate process is ... -
Investigation into gene regulatory networks governing the development and maintenance of the planarian reproductive system
(2024-03-20)Regulation of gene expression is a fundamental mechanism allowing the existence of complex living systems. This regulation takes shape in the form of hierarchical gene regulatory networks (GRNs), culminating in the binding ... -
Computational analysis of transcriptional regulation and chromatin assembly
(2023-12-07)Primordial germ cells (PGCs), the precursors of gametes, are specified from post-implantation epiblast cells in response to bone morphogenetic protein (BMP) signaling at the onset of gastrulation in mouse. Followed by ... -
Understanding the role of the transcription factor MGA in primordial germ cell differentiation
(2023-06-20)One of the most crucial cell lineage decisions in mammalian embryos is the differentiation of a few pluripotent epiblast cells into primordial germ cells (PGCs). PGCs are unique for their ability to mature into either sperm ... -
Mechanisms of chromosome segregation errors in mammalian oocytes
(2023-02-23)During fertilization, a human embryo needs to inherit precisely one copy of each chromosome from both parents. However, human eggs frequently carry an incorrect number of chromosomes, they are aneuploid. Aneuploidy is the ... -
Bioinformatic analysis of multi-omics data elucidates transcriptional cyclin dependent kinase mediated transcriptional regulation
(2022-08-01)Transcriptional regulation is a highly dynamic biological process which is governed by a complex network of proteins for precise expression of a gene. One of the most important regulators of gene expression are cyclin ... -
Understanding Transcriptional Control During Primordial Germ Cell Differentiation
(2022-07-08)AP2γ, encoded by Tfap2c, is a transcription factor which both represses and activates target gene expression. It is required for the survival of the early mouse embryo; depending on the context of its depletion, the loss ...