Browsing Naturwissenschaften, Mathematik und Informatik by Referee "Großhans, Jörg Prof. Dr."
Now showing items 1-16 of 16
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Investigation of cytoplasmic long noncoding RNA in Saccharomyces cerevisiae
(2025-06-12)Research on lncRNAs has increased in the past, but little is known about their function. Recently, discoveries have given us insight into sense- and asRNA regulation in yeast. dsRNA is formed in the nucleus and shuttles ... -
AntisenseRNA mediated gene regulation via double stranded RNA formation
(2023-03-01)The flow of genetic information in eukaryotic cells is established through transcription from the nuclear DNA into messenger (m)RNA, which travels into the cytoplasm for translation into proteins, the functional units of ... -
Characterization of proneural bHLH transcription factor target genes in X. laevis
(2022-09-23)Zc3h12c is a member of the Zc3h12 endoribonuclease family (also known as MCPIP/Regnase), which contains four members (Zc3h12a-c). This family of proteins is characterized by the presence of a single centrally located ... -
Epithelial Cells under Mechanical Strain: an Investigation
(2022-06-29)Cells are the minimal living unit of the body. Each cell plays a vital role that must withstand various stresses, from chemical environments to mechanical strain and temperature variations. One of these vital cell types ... -
Regulation of mechanical feedback amplification in the Drosophila ear
(2022-06-09)Ears achieve their exquisite sensitivity using positive mechanical feedback (Ashmore et al., 2010). Like pushing a swing augments its swing, sound-induced vibrations are enhanced by motile responses of auditory receptor ... -
Biochemical Analysis of Slam – a polarity protein during early Drosophila embryogenesis
(2021-09-23)Slow as molasses (slam) is a gene essential for embryonic development of Drosophila. Slam is necessary for the formation and ingression of the plasma membrane and its polarisation, i.e. the formation of the basal cortical ... -
Investigation of the structure of spliceosomal complexes from the yeast S. cerevisiae
(2021-03-19)Nuclear pre-mRNA splicing is catalysed by the spliceosome, a multi-megadalton ribonucleoprotein (RNP) complex. It assembles de novo for each round of splicing on premRNA intron with stepwise binding of five small nuclear ... -
Active Matter in Confined Geometries - Biophysics of Artificial Minimal Cortices
(2020-12-18)Essential physiological processes, such as cell motility, adhesion, growth and differentiation are determined by the ability of cells to modify their mechanical properties. Consequently, both the vitality as well as ... -
Functional analysis of proteases in tracheal development of Drosophila
(2020-03-11)Formation and remodeling of extracellular matrix (ECM) structures is critical for epithelial development and organ morphogenesis. The apical ECM of epithelial tissues provides a scaffold for cell movements, contributes to ... -
Chromophore-independent roles of Drosophila opsin apoproteins and visual cycle components
(2019-02-13)Visual rhodopsins consist of opsin protein moieties that are covalently bound to 11-cis-retinal, the visual chromophore that is derived from vitamin A. In Drosophila, the visual opsin genes Rh5 and Rh6 were reported to be ... -
Regulation and function of actin nucleators Dia and FMNL in the early Drosophila embryo
(2018-11-19)The formation of the subapical domain during cellularization in Drosophila embryogenesis is mediated by a pathway including the proteins Rap1, Canoe and their downstream effectors Bazooka and Armadillo. The cortical domain ... -
Dynamics of cell contacts during cell intercalation in epithelial tissue elongation of Drosophila embryos
(2017-11-22)Cell rearrangement is one of the fundamental mechanisms underlying tissue morphogenesis. In epithelial tissues, cells rearrange without losing their tight neighbor interactions by junction remodeling according to a topological ... -
Cytoskeletal reorganization in human blood platelets during spreading
(2017-06-21)Anucleate, human blood platelets play an important role in haemostasis to prevent excessive blood loss from a vascular damage. Their actin and microtubule (MT) cytoskeleton is especially responsible for bringing about ... -
A Force Spectroscopy Setup to Mimic Cellular Interaction Processes
(2013-06-21)The main objective of this thesis was to establish a biophysical model system that permits to quantify forces involved in cell-cell contacts and cell-substrate-adhesion in a native-like fashion. For this purpose, colloidal ... -
Membrane mechanics governs cell mechanics in epithelial cell: how surface area regulation ensures tension homeostasis
(2013-04-04)The plasma membrane tension in eukaryotic cells is supposed to be a major regulator of many cellular processes that involve changes in membrane area and membrane deformation including cell migration, mitosis, endo -and ... -
Functional Analysis of Mars (CG17064) in Drosophila Development
(2010-03-31)The formation of the mitotic spindle is controlled by the microtubule organizing activity of the centrosomes and by the effects of chromatin-associated Ran-GTP on the activities of spindle ...