Browsing Naturwissenschaften, Mathematik und Informatik by Referee "Groot, Bert de Prof. Dr."
Now showing items 1-7 of 7
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Leaflet-resolved localization and diffusion of molecules within membranes using metal-induced energy transfer
(2022-05-10)Diffusion is the most fundamental process of molecular transport in cell membranes and an important factor in maintaining its fluidity, controlling the dynamics and functioning of the membrane. In-depth knowledge of membrane ... -
Hydrogen Bonds and Electrostatic Environment of Radical Intermediates in Ribonucleotide Reductase Ia
(2016-06-16)Ribonucleotide reductase connects the RNA and the DNA world via strictly controlled radical chemistry that reduces all four essential ribonucleotides to deoxyribonucleotides. In RNR Ia, the starting point is the µ-oxo ... -
Minimal models for lipid membranes: local modifications around fusion objects
(2013-02-01)Solvent-free soft coarse-grained models are particularly appropriate to investigate collective phenomena in lipid membranes. In this work we exploit such a model to show how modifying a few model parameters we can control ... -
Atomic force microscopy study on the mechanics of influenza viruses and liposomes
(2012-11-28)Physics exists wherever there is matter: measures such as energy, mass, temperature, speed, dimension and stiffness are all examples of the physical properties. Such quantities are important characterizations for ... -
Computer-Aided Drug Design for Membrane Channel Proteins
(2012-09-27)This thesis addresses the non-covalent interaction between small chemical compounds and membrane channel proteins aiming to identify medically relevant lead structures. The first study deals with the optimization of a ... -
Spontaneous aggregation of fibril-forming peptides studied by Molecular Dynamics simulations
(2012-06-21)Polypeptides share the capacity to assemble into fibrillar aggregates with generic properties even though they can be otherwise unrelated in sequence or structure. Moreover, the relevance of peptide aggregation in ... -
Understanding the molecular machinery of aquaporins through molecular dynamics simulations
(2012-01-02)Aquaporins are protein channels responsible for the permeation of water and other small solutes through biological membranes in response to osmotic pressure. The goal of the present thesis ...