Browsing Naturwissenschaften, Mathematik und Informatik by Referee "Rizzoli, Silvio Prof. Dr."
Now showing items 1-15 of 15
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Influence of ezrin's actin binding properties on the formation of minimal actin cortices
(2024-02-16)The cytoskeleton is a pivotal structure within cells, crucial for their motion and life-indispensable processes. The actin cortex is a dense actin network that is part of the cytoskeleton and linked to the plasmamembrane. ... -
Is increased Na+ influx a cause of mitochondrial redox stress, cardiomyopathy, and a therapeutic target?
(2023-11-09)Maintaining balanced Na+ levels is critical for normal functioning of cardiomyocytes, including contractions, excitation-contraction coupling (ECC), and metabolism. The NaV1.5-F1759A (human) mutation, which increases ... -
STED microscopy with two-photon photoactivation in the visible range & Application of generative adversarial networks for image reconstruction in STED microscopy
(2023-01-31)The resolution limit of classical optical far-field microscopes was broken with the invention of super-resolution microscopy. Today, a variety of these techniques achieving different degrees of resolution exist. Image formation ... -
Epithelial Cells under Mechanical Strain: an Investigation
(2022-06-29)Cells are the minimal living unit of the body. Each cell plays a vital role that must withstand various stresses, from chemical environments to mechanical strain and temperature variations. One of these vital cell types ... -
Advanced multiplexing techniques in single molecule localisation microscopy
(2022-05-13)DNA point accumulation for imaging in nanoscale topography (DNA-PAINT) is a powerful super-resolution technique highly suitable for multi-target (multiplexing) bio-imaging applications. However, multiplexed imaging of cells ... -
Proteomic analysis of synaptic dysfunction in the hippocampus of late-stage Parkinson´s Disease
(2022-04-01)The present study focussed on assessing changes in the hippocampus as a result of late-stage Parkinson´s disease. Human post-mortem hippocampal samples were used to address these changes, quantifying significant alterations ... -
Synthesis of Modified Biomolecules to Investigate Neuronal Processes
(2021-04-30)Action potentials are an essential process for signal transmission in excitable cells. At chemical synapses, the action potential triggers the release of neurotransmitters from synaptic vesicles to transmit the signal to ... -
Insights into the regulation of RNA helicases by protein cofactors
(2019-02-12)RNA helicases comprise a large family of ubiquitously expressed enzymes that remodel RNA structures and RNA-protein complexes in an NTP-dependent manner. These proteins are essential regulators of every RNA-related process, ... -
Charakterisierung der Aktivität und Inhibition des rekombinanten, spannungsgesteuerten Protonenkanals HV1: Funktionelle Rekonstitution in unilamellare Vesikel
(2018-10-15)The human voltage-gated proton channel (hHV1) regulates important physiological processes like the respiratory burst activity of white blood cells and the motility of spermatozoa by efflux of protons. Reconstitution of the ... -
Genetic and Pharmacological Modulation of Alpha-Synuclein Aggregation
(2017-07-18)Several neurodegenerative disorders, such as Parkinson’s disease (PD), are characterized by the deposition of misfolded and aggregated forms of a particular protein in different areas of the brain. Understanding the molecular ... -
Amyloid-beta driven changes in transcriptome plasticity: From OMICS to Therapy
(2016-04-06)Alzheimer’s disease is characterized by a progressive cognitive decline coinciding with the formation of amyloid plaques and tau fibrils in the human brain. It is the most common form of dementia and the number of people ... -
Extracellular vesicle release of α-Synuclein is mediated by SUMOylation
(2015-11-13)We hypothesized that cells release and transfer α-Syn associated with EVs, followed by highly efficient internalization and induction of α-Syn aggregation in previously healthy neurons. EVs of 40-100 nm diameter can either ... -
Differential gene expression of chemokines in KRAS and BRAF mutated colorectal cell lines: Role of cytokines
(2013-06-07)Background: Worldwide, colorectal cancer is the third most common malignancy. The development of the colorectal cancer (CRC) is a multistep process that involves e.g. an accumulation of mutations in tumor-growth promoting ... -
Investigation of myelin membrane adhesion and compaction in the central nervous system
(2013-02-13)Myelin is a multi-layered membrane which enwraps the axons in peripheral (PNS) and central nervous system (CNS). The formation and assembly of this structure is a multi-step process that is regulated by a variety of ... -
Synaptic vesicle recycling <i>in Vivo</i>
(2012-03-12)The basic mechanism of neurotransmitter release at synapses is relatively well understood: upon arrival of an action potential, calcium influx into the nerve terminal triggers fusion of ...