Browsing Naturwissenschaften, Mathematik und Informatik by Referee "Tietze, Lutz Prof. Dr. Dr. h.c."
Now showing items 1-20 of 33
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Diversity-Oriented Assembly of C-Glycosides via Late-Stage C−H Glycosylation
(2023-08-29)C-glycosides are widely distributed structural motifs found in natural products and commercially available drug molecules. Due to the stability of glycosidic C-C bonds against chemical and enzymatic hydrolysis, only ... -
Sustainable Methods in C–H Functionalizations
(2023-05-30)Cross-coupling chemistry has matured in an attractive tool in synthetic organic chemistry to realized efficient formation of C‒C and C‒Het bonds. However, these transformations are also associated with certain drawbacks, ... -
Transition Metal- and Electro-Catalyzed C-H and B-H Activation for the Efficient Synthesis of Carborane Derivatives
(2023-01-12)The emergence and rapid development of transition metal-and electro-catalyzed C-H activation has proven to be a powerful tool in the assembly of complex molecular structures. in addition, the selective synthesis of carborane ... -
Resource-Economical C–H Activation for Late-Stage Functionalization
(2021-07-07)Organic synthesis has traditionally relied on step-, time- and resource-intensive strategies, namely the functional group interconversion and, more recently, on cross-coupling reactions. These approaches have enabled the ... -
Cobalt(III)- and Manganese(I)-Catalyzed C-H and C-C Activations
(2019-03-28)Metal-catalyzed C─H and C─C functionalizations have become an increasingly viable approach, which allows the direct formation of C─C and C─heteroatom bonds in an atom- and step-economical manner. However, the significant ... -
Domino-Reaktionen mit anti-Carbopalladierungen an Alkinen als Schlüsselschritt und Transformationen von Arylthiocyanaten mit Arinen
(2015-09-09)The work presents a formal anti-carbopalladation reaction of alkynes imbedded into a domino reaction for the synthesis of oligo cyclic structures. Therefore, intra- as well as intermolecular approaches were performed. ... -
Domino Reactions for the Syntheses of Chiral Chromanes ‒ Enantioselective Total Syntheses of (‒)-Diversonol, (‒)-Blennolide C, (‒)-Gonytolide C and Formal Synthesis of Siccanin
(2015-06-15)The general objective of this thesis is to demonstrate the synthetic utility of the domino concept in the complex setting of natural product synthesis. Key step is a palladium-catalyzed domino Wacker/carbonylation/methoxylation ... -
Synthese und biologische Evaluation neuartiger Duocarmycin-Analoga für eine selektive Krebstherapie
(2013-06-07)To date most anticancer agents interact with the cell cycle and therefore traditionally damage only cells with high proliferation rates. The usually insufficient differentiation between normal and malignant cells results ... -
Synthese und biologische Evaluierung neuartiger Acronycin-Duocarmycin-Hybride
(2012-02-17)A new hybrid comprising the structure of natural products acronycine and duocarmycin was synthesized and biologically evaluated. -
Oxygen Bridged Metal Systems: Heterometallic Compounds Containing Main Group Metal, Transtion Metal and f-Elements
(2011-10-31)This dissertation lays emphasis mainly on the synthesis and structural studies of oxygen bridged heterobi- and trimetallic complexes containing main group metal, transition metal and ... -
Experimental Electron Density Determination of Unconventionally Bonded Boron
(2009-07-22)Two major aims have been pursued in the course of this thesis. On the one hand, reasons for the different reactivities of two Lewis acids based on tris(pentafluorophenyl)borane, namely ... -
Entwicklung katalytischer Kreuzkupplungs- und Hydroaminierungsreaktionen
(2008-11-13)In recent years great efforts have been taken for the development of highly active catalysts in the field of hydroamination- and cross-coupling-reactions. However, there is still a lack of ... -
Synthesis of Diverse Polyfunctional Amides as Precursors to Potentially Interesting Peptidomimetics
(2008-10-22)First chapter is dedicated to the applying of the Ugi multicomponent reaction for the synthesis of the compound containing small ring systems such as cyclopropane and its structure ... -
Totalsynthese von Camptothecin
(2008-10-22)The pentacyclic alkaloid camptothecin exhibits pronounced cytotoxicity. Within the framework of structure-property-relationship studies irinotecan (camptosar®) and topotecan (hycamtin®) as ... -
Catalytic Insertion Reactions into the Cyclopropane Ring Syntheses of Various Belactosin C Congeners and Analogues
(2008-09-17)Catalytic insertion reactions of various cyclic (4-phenyl-1,2,4-triazoline-3,5-dione, PTAD) and acyclic (azobenzene, ethyl phenyldiazenecarboxylate and diisopropyl azodicarboxylate) diazene ... -
Synthesis and X-ray Structural Characterization of Oxygen Bridged Complexes for Olefin Polymerization: A Theoretical Interpretation of Structure and Activity Relationship
(2007-11-22)This PhD thesis describes the synthesis and X-ray structural studies of oxygen bridged heterobi- and trimetallic complexes for olefin polymerization reactions. First part of work describes the preparation and characterization ... -
Evaluierung des Antibody Directed Enzyme Prodrug Therapy-Konzepts im Mammakarzinom- und Lymphom-Mausmodell
(2007-10-31)The aim of this study was in vivo evaluation of a new tumor therapy called Antibody Directed Enzyme Prodrug Therapy (ADEPT). This therapy should give a high specificity and selectivity for ... -
Synthese von Tetragastrin-CC-1065-Konjugaten und verwandten Verbindungen für eine selektive Krebstherapie
(2007-06-19)The antibiotic (+)-CC-1065 was first isolated from culture of Streptomyces zelensis in 1978. It showed in both in vitro and in vivo performed screenings very high cell toxicity. The study ... -
Synthesis and Application of new chiral Peptides, Guanidines and Formamides as Organocatalysts for Asymmetric C-C Bond Formation Reactions
(2007-02-07)For this Ph. D. thesis I synthesized chiral peptides, guanidines and formamides and used them as organocatalysts in asymmetric C-C bond formation reactions. Here I demonstrated that small ... -
Der Einfluß von chemischer Konstitution, Symmetrie und molekularer Umgebung auf die intramolekulare Schwingungsrelaxation aromatischer Moleküle
(2006-03-24)This thesis focuses on elucidating mechanisms of intramolecular vibrational energy redistribution (IVR). It constitutes a comparative study on structurally closely related aromatic molecules ...