Naturwissenschaften, Mathematik und Informatik
Recent Submissions
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Advancing Explainable AI in Medicine: Novel Frameworks for Robustness, Evaluation, and Human-Centered Interpretability
(2025-06-23)The advancement of artificial intelligence (AI) has led to its increasing usage in various fields, including medicine, where AI models, particularly deep neural networks (DNNs), have shown great performance. However, ... -
Movement ecology of Guinea baboons (Papio papio)
(2025-06-23)Access to critical resources such as food, water, shelter, or mates can be a significant determinant of the fitness of animals. In habitats where specific resources are limited, there is high potential for resource ... -
HMGB2 programming and structural variations as tumor supportive mechanisms in cancer
(2025-06-17)Cancer is a widespread disease that affects many. In order to escape into malignancy, a cell has to undergo a multistep process during which it acquires a set of traits. These traits allow it to replicate indefinitely and ... -
CNS myelin heterogeneity in species, single myelin sheaths and in Multiple Sclerosis
(2025-06-16)In the Central Nervous System (CNS), oligodendrocytes (OLGs) produce myelin which is a specialized plasma membrane that supports axons. Similarly, Schwann Cells (SCs) fulfill this role in the Peripheral Nervous System ... -
Exploring Transient Dialumene and Diazido-Dialane: Low Oxidation State Aluminium Chemistry based on a Hybrid Ligand
(2025-06-12)This thesis focuses on the exploration and development of the hybrid NacNac-Box-akin ligand, DippNac-Indole (DNI), and its application in stabilizing low oxidation state aluminium complexes. The study is structured to ... -
Axial and Equatorial Ligand Effects of Bioinspired Tetracarbene Iron Models for Heme and Non-Heme Enzymes
(2025-06-12)The selective oxidation of hydrocarbons with sustainable oxidants is still a challenging reaction in industry. In order to create a sustainable future—especially in regard of progressing climate change—finding alternative ... -
Synthesis and Adhesion Properties of E-Cadherin Mimetic Peptides
(2025-06-12)Cell adhesion molecules (CAMs) are essential for various biological processes, including tissue homeostasis and wound healing. One such molecule, the calcium-dependent protein E-cadherin, is primarily expressed at adherens ... -
Dynamics of active condensation
(2025-06-12)Active matter represents a unique class of out-of-equilibrium systems, that are ubiquitous in our everyday life. Active particles convert energy into mechanical motion and this leads to collective self-organization into ... -
Nuclear Resonances in X-ray Waveguides
(2025-06-12)Hard X-rays generally only interact very weakly with matter, so that tissue, for example, is quite transparent to them. However, this makes the controlled manipulation of X-ray light particularly challenging. While many ... -
Investigation of cytoplasmic long noncoding RNA in Saccharomyces cerevisiae
(2025-06-12)Research on lncRNAs has increased in the past, but little is known about their function. Recently, discoveries have given us insight into sense- and asRNA regulation in yeast. dsRNA is formed in the nucleus and shuttles ... -
Nanoscale optoelectronic characterization of graphene-based heterostructures
(2025-06-11)The ongoing downscaling of electronic devices requires innovative approaches to probe and manipulate electronic behavior at the nanoscale. Two-dimensional (2D) materials offer a remarkable opportunity to directly explore ... -
Winter Hardiness and Freezing Tolerance of Winter Faba Bean (Vicia faba L.): From QTL Identification and Validation to Genome-Wide Predictions of Genotypic Values
(2025-06-11)The growing interest in plant-based proteins and a more sustainable agricultural system, with wider crop rotations, reduced fertilizer input, and increased crop and fauna diversity, has intensified in response to climate ... -
C-H Bond Activation by Iridium(III) and Iridium(IV) Oxo Complexes
(2025-06-11)C−H activation by two isostructural, terminal iridium(III) and iridium(IV) oxo complexes is compared. While the driving forces for hydrogen abstraction are almost identical due to compensating contributions from H+ and e− ... -
Advancing CRISPR gene therapy for Noonan syndrome: Targeting recurrent LZTR1 variants with all-in-one Cas9 and base editors in patient-derived iPSC-cardiomyocytes
(2025-05-28)Pathogenic variants in LZTR1 are causative for Noonan syndrome with early onset of a severe hypertrophic cardiomyopathy. Despite high clinical relevance, therapeutic options are highly limited, and no curative treatment ... -
Structure and Evolution of Visual Cortical Representations
(2025-05-28)Fully understanding the functions and mechanisms of the complex machinery that is our brain requires advanced statistical data analysis and theoretical modelling. In this thesis, I develop and apply statistical tools and ... -
Transformation of waste gases into biocommodities by syngas fermentation
(2025-05-28)This study describes a total of 13 novel gas-fermenting strains from four different bacterial genera. Three strains represent a new species. These acetogenic and carboxydotrophic hydrogenogenic strains were successfully ... -
Measurement of top quark pair production in association with charm quarks at √s = 13 TeV with the ATLAS detector
(2025-05-28)The Large Hadron Collider at CERN has produced a uniquely large set of proton-proton collision data at never-before-seen energies since the beginning of its operation in 2010. Using data collected by the ATLAS detector ... -
Tau oligomers and stress granules: Molecular insights into slowly and rapidly progressive Alzheimer’s disease
(2025-05-27)Alzheimer’s disease (AD) exhibits substantial clinical and molecular heterogeneity, with rapidly progressive AD representing a distinct and aggressive subtype. This study provides an in-depth characterization of stress ... -
Painting a bigger picture on response of European beech (Fagus sylvatica L.) to climate change – past vs. status quo
(2025-05-22)Impacts of climate change on forest ecosystems are becoming more visible than ever before. Whereas the performance of European forests is of great ecological as well as of economic importance, the term “vitality” itself ... -
Dendroclimatic investigation of European beech growth dynamics along a precipitation gradient in northern Germany
(2025-05-22)This thorough study of European beech (Fagus sylvatica) growth limits in Northern Germany shows the major difficulties caused by climate change and global warming. Drawing on the findings of three main chapters, we arrive ...