Einfluss des Gravitational Platelet Separation System (GPS®-System) auf den postoperativen klinischen Verlauf nach medianer Sternotomie bei herzchirurgischem Eingriff

Influence of the Gravitational Platelet Separation System (GPS®-System) on the postoperative clinical course following median sternotomy in cardiothoracic surgery

by Andreas Drescher
Doctoral thesis
Date of Examination:2019-08-06
Date of issue:2019-07-24
Advisor:Prof. Dr. Bernhard C. Danner
Referee:Prof. Dr. Bernhard C. Danner
Referee:PD Dr. Joachim Riggert
Persistent Address: http://dx.doi.org/10.53846/goediss-7564

 

 

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Abstract

English

Platelet-rich plasma is used in various fields of medicine, especially to improve wound healing and reduce wound healing disorders. The present study investigated the influence of the application of a platelet-rich plasma in the wound area after median sternotomy on 300 patients. During the follow-up period of 30 days the postoperative clinical course was recorded (wound and sternum status, need for revision surgery, blood loss, laboratory markers of inflammation e.g.). For platelet-rich plasma in cardiothoracic surgery, no significant effects could be shown in this prospective study design. Furthermore, we developed a predictive model, based on the available postoperative data, to identify patients with need for reoperation caused by sternal wound infection.
Keywords: PRP; platelet-rich plasma; cardiothoracic surgery; wound healing; deep sternal wound infection
 
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