| dc.contributor.advisor | Pukrop, Tobias Prof. Dr. | |
| dc.contributor.author | Jautz, Jonas | |
| dc.date.accessioned | 2019-07-31T08:11:13Z | |
| dc.date.available | 2019-08-07T22:50:03Z | |
| dc.date.issued | 2019-07-31 | |
| dc.identifier.uri | http://hdl.handle.net/21.11130/00-1735-0000-0003-C181-0 | |
| dc.identifier.uri | http://dx.doi.org/10.53846/goediss-7563 | |
| dc.identifier.uri | http://dx.doi.org/10.53846/goediss-7563 | |
| dc.language.iso | deu | de |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject.ddc | 610 | de |
| dc.title | Einfluss von Mifamurtid auf die Makrophagen-induzierte Tumorinvasion von Brustkrebszellen | de |
| dc.type | doctoralThesis | de |
| dc.title.translated | The influence of Mifamurtid on the macrophage-induced tumorinvasion of breastcancer | de |
| dc.contributor.referee | Pukrop, Tobias Prof. Dr. | |
| dc.date.examination | 2019-07-31 | |
| dc.description.abstracteng | Worldwide, breast cancer is the most-common invasive cancer in women. Despite of advancing treatment options, women still die due to dissemination and metastasis formation. It is known that tumor-associated macrophages (TAMs) promote tumor invasion and metastasis of breast cancer cells. In this dissertation the effect of Mifamurtid, a potent immunomodulator approved for the treatment of progressive osteosarcoma, on the macrophage-induced tumor invasion was analyzed. The results showed that Mifamurtid causes a significant reduction in macrophage-induces tumor invasion. However, a direct effect on tumor invasion was detected and it was shown that different breast cancer cell lines express the potential receptors for Mifarmutid in a varying degree. Therefore, it needs to be further elucidated, whether the here shown effect is due to an activation of the macrophages or result from a direct effect on the tumor cells. | de |
| dc.contributor.coReferee | Reichardt, Holger Prof. Dr. | |
| dc.subject.eng | macrophage-induced tumor invasion | de |
| dc.identifier.urn | urn:nbn:de:gbv:7-21.11130/00-1735-0000-0003-C181-0-1 | |
| dc.affiliation.institute | Medizinische Fakultät | de |
| dc.subject.gokfull | Nachschlagewerke {Medizin} (PPN620300566) | de |
| dc.description.embargoed | 2019-08-07 | |
| dc.identifier.ppn | 1672307104 | |