C-H Activation by Nickel and Iron Catalysis
von Thomas Müller
Datum der mündl. Prüfung:2019-06-16
Erschienen:2019-08-08
Betreuer:Prof. Dr. Lutz Ackermann
Gutachter:Prof. Dr. Lutz Ackermann
Gutachter:Prof. Dr. Konrad Koszinowski
Gutachter:Prof. Dr. Ricardo Mata
Gutachter:Dr. Sebastian Kruss
Gutachter:Dr. Michael John
Gutachter:Dr. Shoubhik Das
Dateien
Name:Dissertation_Thomas Müller.pdf
Size:28.8Mb
Format:PDF
Zusammenfassung
Englisch
The thesis contents methods for the selective activation and functionalization of C–H bonds, among the most abundant bonds in organic molecules. In particular, earth-abundant and cost-effective nickel and iron complexes were utilized for C–H activation reactions, namely the nickel-catalyzed C–H chalcogenations of aniline derivatives with diaryl dichalcogenides and nickel-catalyzed C–H allylations and alkenylations of heteroarenes with allenes. Furthermore, methodologies for the construction of biologically relevant isoquinoline structures via iron-catalyzed C-H activation/annulation reactions using allenyl acetates or propargyl acetates have been developed.
Keywords: C-H activation; Nickel; Iron; Catalysis; chalcogenation; allylation; alkenylation; annulation; isoquinoline synthesis