C-H Activation by Nickel and Iron Catalysis

by Thomas Müller
Doctoral thesis
Date of Examination:2019-06-16
Date of issue:2019-08-08
Advisor:Prof. Dr. Lutz Ackermann
Referee:Prof. Dr. Lutz Ackermann
Referee:Prof. Dr. Konrad Koszinowski
Referee:Prof. Dr. Ricardo Mata
Referee:Dr. Sebastian Kruss
Referee:Dr. Michael John
Referee:Dr. Shoubhik Das
Persistent Address: http://dx.doi.org/10.53846/goediss-7560

 

 

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Abstract

English

The thesis contents methods for the selective activation and functionalization of C–H bonds, among the most abundant bonds in organic molecules. In particular, earth-abundant and cost-effective nickel and iron complexes were utilized for C–H activation reactions, namely the nickel-catalyzed C–H chalcogenations of aniline derivatives with diaryl dichalcogenides and nickel-catalyzed C–H allylations and alkenylations of heteroarenes with allenes. Furthermore, methodologies for the construction of biologically relevant isoquinoline structures via iron-catalyzed C-H activation/annulation reactions using allenyl acetates or propargyl acetates have been developed.
Keywords: C-H activation; Nickel; Iron; Catalysis; chalcogenation; allylation; alkenylation; annulation; isoquinoline synthesis
 
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