Persönlichkeit, neurohumorale Aktivierung, Bindungsstile und subjektives Befinden bei Patienten mit kardiovaskulären Risikofaktoren oder Herzinsuffizienz aus der Diast-CHF-Studie
Personality, neurohumoral activation, attachment and subjective well-being in patients with cardiovascular risk factors or heart failure from the Diast-CHF study
von Monika Sadlonova
Datum der mündl. Prüfung:2019-10-17
Erschienen:2019-09-11
Betreuer:Prof. Dr. Christoph Herrmann-Lingen
Gutachter:Prof. Dr. Christoph Herrmann-Lingen
Gutachter:Prof. Dr. Claudius Jacobshagen
Dateien
Name:Doktorarbeit - eDiss.pdf
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Description:Persönlichkeit, neurohumorale Aktivierung, Bindungsstile und subjektives Befinden bei Patienten mit kardiovaskulären Risikofaktoren oder Herzinsuffizienz aus der Diast-CHF-Studie
Zusammenfassung
Englisch
Background: Chronic heart failure (HF) is one of the most important health problems in the industrialized world. Several hormonal systems are involved in the pathophysiology of HF. The activation of GDF-15 leads to a cardioprotective effect. In contrast, the secretion of galectin-3 causes cardiac remodeling processes. CT-proAVP can be used to estimate vasopressin secretion and as a biomarker of heart failure. Methods: In our research, we included 1510 patients with cardiovascular risk factors for HF or with a verified diagnosis of HF from the observational Diagnostic Trial on Prevalence and Clinical Course of Diastolic Dysfunction and Diastolic Heart Failure study (“Diast-CHF“). We analyzed the relationships between factors of neurohumoral activation (CT-proAVP, GDF-15, galectin-3), mental health, attachment, the presence of a type D personality, the health-related quality of life and self-efficacy with validated instruments. Results: In our study (N = 1510, mean age 66.8 ± 8.0, 51.3% males), there was an association between CT-proAVP and anxiety scores, Rho (ρ) = -.086 and the physical quality of life (ρ = -.079). There was a negative association between the GDF-15 concentration and the physical quality of life (ρ = -.233). There was also a negative correlation between galectin-3 and the anxiety scale (ρ = -.076) as well as a positive association with the mental quality of life (ρ =.062). The associations between galectin-3 and CT-proAVP with the anxiety scale and between CT-proAVP and GDF-15 with physical quality of life were independent of NT-proBNP, LVEF and diastolic dysfunction. Conclusions: Our exploratory data analysis shows a negative association between anxiety and CT-proAVP as well as galectin-3 levels. In addition, there is a negative association between the CT-proAVP and GDF-15 concentrations and the physical quality of life. The galectin-3 levels correlated positively with the mental quality of life. The investigated biomarkers could help to better understanding of the relationships between the physical and mental health in patients with cardiovascular risk factors or heart failure.
Keywords: heart failure; CT-proAVP; GDF-15; galectin-3; anxiety; health-related quality of life