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dc.contributor.advisor Eichele, Gregor Prof. Dr. Günther, Ann-Kathrin 2019-09-13T09:07:58Z 2019-09-13T09:07:58Z 2019-09-13
dc.language.iso eng de
dc.subject.ddc 530 de
dc.title Transport of lipid vesicles via the cilia logistic network in the brain of mice de
dc.type doctoralThesis de
dc.contributor.referee Eichele, Gregor Prof. Dr. 2018-09-21
dc.subject.gok Physik (PPN621336750) de
dc.description.abstracteng The ventricular system of the mammalian brain consists of four interconnected cavities, which are lined by ciliated ependymal cells. Constant and coordinated movement of the cilia results in a directed flow of cerebrospinal fluid (CSF) along the ependymal walls. In the ventral part of the third ventricle (v3V) the cilia give rise to a complex network of flow that confines and connects regions. This so-called ciliary logistic network (CLN) may provide transport routes for CSF components (e.g. extracellular vesicles) and has the potential to guide and restrict the distribution of local secretions. It is unclear, how extracellular vesicles like exosomes are distributed throughout the ventricular system and whether the CLN mediates site-specific deliveries of exosomes. In this thesis, a characterization of exosome-like cargo transport along the CLN and potential target sites in the v3V of the mouse brain are presented. To investigate the transport and interaction of exosome-like cargo, fluorescently-labelled liposomes of defined composition and size were applied to the cilia-generated near wall flow via microinjections. The results of this work reveal that the transport of lipid vesicles within the v3V is determined by the cilia-generated flow. Liposomes are transported with high precision and interact with ependymal cilia in specific regions. de
dc.contributor.coReferee Bodenschatz, Eberhard Prof. Dr.
dc.subject.eng ventral thrid ventricle de
dc.subject.eng cilia-generated flow de
dc.subject.eng liposomes de
dc.subject.eng extracellular vesicles de
dc.subject.eng ciliary logistic network de
dc.subject.eng CSF transport de
dc.identifier.urn urn:nbn:de:gbv:7-21.11130/00-1735-0000-0003-C1B9-2-7 Fakultät für Physik de
dc.identifier.ppn 1676963162

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