Sustainable Synthesis by 3d Transition Metal Electro-Catalyzed C─H Activation
by Cuiju Zhu
Date of Examination:2019-12-10
Date of issue:2020-01-20
Advisor:Prof. Dr. Lutz Ackermann
Referee:Prof. Dr. Lutz Ackermann
Referee:Prof. Dr. Alexander Breder
Referee:Prof. Dr. Konrad Koszinowski
Referee:Prof. Dr. Manuel Alcarazo
Referee:Dr. Holm Frauendorf
Referee:Dr. Michael John
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EnglishDuring the last years, new opportunities are represented by the development of 3d transition metal-catalyzed C–H activation, with possible benefits due to the significantly lower toxicity, high natural abundance and cost-effective nature of the employed metal catalysts. Within this thesis, two complexity-increasing domino reactions catalyzed by Cobalt and Manganese catalysts were developed. Furthermore, the first sustainable manganese(II/III/I)-catalyzed C–H arylations in continuous flow technology were achieved. Additionally, toxic and cost-intensive dihalide oxidants were for the first time replaced by electricity as a green and sustainable oxidant, allowing for versatile iron- and manganese-catalyzed C–H activations.
Keywords: 3d Transition Metal; Cobalt; Manganese; Domino Reaction; Continuous Flow; Electrochemistry.