Strukturelle und funktionelle Charakterisierung Filaggrin/Hornerin defizienter (FlgHrnr-/-) Mäuse

Structural and functional characterisation of filaggrin-hornerin (FlgHrnr-/- ) double-deficient mice

by Sebastian Rahrig
Doctoral thesis
Date of Examination:2020-03-05
Date of issue:2020-02-14
Advisor:Prof. Dr. Michael P. Schön
Referee:Prof. Dr. Lutz Walter
Referee:Prof. Dr. Thomas Meyer
Persistent Address: http://dx.doi.org/10.53846/goediss-7853

 

 

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Abstract

English

Filaggrin (Flg) and hornerin (Hrnr) share similar structural and functional features. Both proteins have been implicated as essential proteins for skin barrier maintenance. Loss-of-function mutations of these genes constitute a risk factor for atopic dermatitis and eczema-related asthma. Furthermore, both FLG and HRNR protein levels are downregulated in patients with atopic dermatitis. Thus, mice deficient for Flg and Hrnr provide a novel model to study skin barrier impairment and the susceptibility for cutaneous inflammation.
Keywords: allergic contact dermatitis; filaggrin; homerin; skin barrier
Schlagwörter: allergische Kontaktdermatitis; Filaggrin; Hornerin; Hautbarriere
 
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