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dc.contributor.advisor Schön, Michael P. Prof. Dr.
dc.contributor.author Rahrig, Sebastian
dc.date.accessioned 2020-02-14T13:51:26Z
dc.date.available 2020-03-12T23:50:03Z
dc.date.issued 2020-02-14
dc.identifier.uri http://hdl.handle.net/21.11130/00-1735-0000-0005-1320-1
dc.language.iso deu de
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc 610 de
dc.title Strukturelle und funktionelle Charakterisierung Filaggrin/Hornerin defizienter (FlgHrnr-/-) Mäuse de
dc.type doctoralThesis de
dc.title.translated Structural and functional characterisation of filaggrin-hornerin (FlgHrnr-/- ) double-deficient mice de
dc.contributor.referee Walter, Lutz Prof. Dr.
dc.date.examination 2020-03-05
dc.description.abstracteng Filaggrin (Flg) and hornerin (Hrnr) share similar structural and functional features. Both proteins have been implicated as essential proteins for skin barrier maintenance. Loss-of-function mutations of these genes constitute a risk factor for atopic dermatitis and eczema-related asthma. Furthermore, both FLG and HRNR protein levels are downregulated in patients with atopic dermatitis. Thus, mice deficient for Flg and Hrnr provide a novel model to study skin barrier impairment and the susceptibility for cutaneous inflammation. de
dc.contributor.coReferee Meyer, Thomas Prof. Dr.
dc.subject.ger allergische Kontaktdermatitis de
dc.subject.ger Filaggrin de
dc.subject.ger Hornerin de
dc.subject.ger Hautbarriere de
dc.subject.eng allergic contact dermatitis de
dc.subject.eng filaggrin de
dc.subject.eng homerin de
dc.subject.eng skin barrier de
dc.identifier.urn urn:nbn:de:gbv:7-21.11130/00-1735-0000-0005-1320-1-0
dc.affiliation.institute Medizinische Fakultät de
dc.subject.gokfull Dermatologie / Venerologie - Allgemein- und Gesamtdarstellungen (PPN619876174) de
dc.description.embargoed 2020-03-12
dc.identifier.ppn 1690089806

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