Strukturelle und funktionelle Charakterisierung Filaggrin/Hornerin defizienter (FlgHrnr-/-) Mäuse

Rahrig, Sebastian

dc.contributor.advisor	Schön, Michael P. Prof. Dr.
dc.contributor.author	Rahrig, Sebastian
dc.date.accessioned	2020-02-14T13:51:26Z
dc.date.available	2020-03-12T23:50:03Z
dc.date.issued	2020-02-14
dc.identifier.uri	http://hdl.handle.net/21.11130/00-1735-0000-0005-1320-1
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-7853
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	610	de
dc.title	Strukturelle und funktionelle Charakterisierung Filaggrin/Hornerin defizienter (FlgHrnr-/-) Mäuse	de
dc.type	doctoralThesis	de
dc.title.translated	Structural and functional characterisation of filaggrin-hornerin (FlgHrnr-/- ) double-deficient mice	de
dc.contributor.referee	Walter, Lutz Prof. Dr.
dc.date.examination	2020-03-05
dc.description.abstracteng	Filaggrin (Flg) and hornerin (Hrnr) share similar structural and functional features. Both proteins have been implicated as essential proteins for skin barrier maintenance. Loss-of-function mutations of these genes constitute a risk factor for atopic dermatitis and eczema-related asthma. Furthermore, both FLG and HRNR protein levels are downregulated in patients with atopic dermatitis. Thus, mice deficient for Flg and Hrnr provide a novel model to study skin barrier impairment and the susceptibility for cutaneous inflammation.	de
dc.contributor.coReferee	Meyer, Thomas Prof. Dr.
dc.subject.ger	allergische Kontaktdermatitis	de
dc.subject.ger	Filaggrin	de
dc.subject.ger	Hornerin	de
dc.subject.ger	Hautbarriere	de
dc.subject.eng	allergic contact dermatitis	de
dc.subject.eng	filaggrin	de
dc.subject.eng	homerin	de
dc.subject.eng	skin barrier	de
dc.identifier.urn	urn:nbn:de:gbv:7-21.11130/00-1735-0000-0005-1320-1-0
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Dermatologie / Venerologie - Allgemein- und Gesamtdarstellungen (PPN619876174)	de
dc.description.embargoed	2020-03-12
dc.identifier.ppn	1690089806

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Human- und Zahnmedizin [2872]

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