Novel approaches to measure physiological and behavioral responses to stress

Seidel, Jan

dc.contributor.advisor	Ehrenreich, Hannelore Prof. Dr. Dr.
dc.contributor.author	Seidel, Jan
dc.date.accessioned	2020-02-21T10:45:36Z
dc.date.available	2020-02-21T10:45:36Z
dc.date.issued	2020-02-21
dc.identifier.uri	http://hdl.handle.net/21.11130/00-1735-0000-0005-132F-2
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-7845
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-7845
dc.language.iso	eng	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	570	de
dc.title	Novel approaches to measure physiological and behavioral responses to stress	de
dc.type	cumulativeThesis	de
dc.contributor.referee	Ehrenreich, Hannelore Prof. Dr. Dr.
dc.date.examination	2019-12-02
dc.description.abstracteng	Stress is the perception of threats to one's physical or psychological integrity, leading to certain autonomous, affective, and behavioral responses. Albeit its important role in adapting to new contexts and thus increasing chances of survival, severe - but also mild, chronic - forms of stress can lead to inappropriate behavioral patterns and even to physical and mental health issues. This thesis' aim is to deepen our understanding of stress responses via two different approaches: In Project I, we investigate the effects of negative early life experiences on violent aggressive behavior in four schizophrenia samples and two additional samples from the general population. Over all groups we showed that an accumulation of specific, well-defined, pre-adult environmental risk factors is strongly associated with aggression, not only in patients suffering from schizophrenia but also in individuals from the general population. Furthermore, we found elevated mRNA levels of histone deacetylase 1, a gene encoding an important epigenetic modulator, in individuals with a high amount of negative early life experiences. These results suggest that our models of accumulated environmental risk are suitable to accurately predict aggressive potential in both schizophrenia patients and healthy individuals. In Project II, we introduce a novel method for non-invasively measuring autonomous responses to social stress and its impact on the recognition ability in both mice and healthy men. In this translational study, we derived body surface temperatures via infrared thermography recordings in order to create ambient-independent, intraindividually adjusted thermal indices as readouts of stress. Considering the methodological limitations of former thermographic research, we describe and evaluate the quality of an innovative procedure to use infrared thermography, including a standardized pipeline of image recording as well as processing, data extraction, and analysis. This work contributes to our understanding of physiological and psychological stress responses and has several important implications for future research.	de
dc.contributor.coReferee	Penke, Lars Prof. Dr.
dc.subject.eng	clinical neuroscience	de
dc.subject.eng	early life risk	de
dc.subject.eng	epigenetics	de
dc.subject.eng	flushing	de
dc.subject.eng	human study	de
dc.subject.eng	infrared thermography	de
dc.subject.eng	mouse models of social learning	de
dc.subject.eng	risk accumulation	de
dc.subject.eng	social stimulus	de
dc.subject.eng	stress measurement	de
dc.subject.eng	temperature	de
dc.subject.eng	translational study	de
dc.subject.eng	vasoactivity	de
dc.subject.eng	violent aggression	de
dc.identifier.urn	urn:nbn:de:gbv:7-21.11130/00-1735-0000-0005-132F-2-7
dc.affiliation.institute	Göttinger Graduiertenschule für Neurowissenschaften, Biophysik und molekulare Biowissenschaften (GGNB)	de
dc.subject.gokfull	Biologie (PPN619462639)	de
dc.identifier.ppn	1690813865

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Das Dokument erscheint in:

GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften [1114]
GGNB - Göttingen Graduate Center for Neurosciences, Biophysics and Molecular Biosciences

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