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Etablierung von zirkulierenden DNA-Fragmenten als Biomarker für die klinische Progression einer Herzinsuffizienz mit erhaltener Ejektionsfraktion

Establishing predictive modelling of heart failure with preserved ejection fraction progression

by Marleen Awe
Doctoral thesis
Date of Examination:2020-02-25
Date of issue:2020-02-21
Advisor:Prof. Dr. Elisabeth Zeisberg
Referee:Prof. Dr. Thomas Meyer
Referee:Prof. Dr. Martin Oppermann
crossref-logoPersistent Address: http://dx.doi.org/10.53846/goediss-7873

 

 

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Abstract

English

Chronic heart disease is associated with abberant CpG promoter methylation, mechanistically involved cardiac fibrogenesis. Aberant CpG promoter methylation is equally reflected in corresponding blood samples („liquid biopsy“). Established HFpEF markers poorly correlate with circulating methylated RASAL1, B9D1 and ATP2A2. Established HFpEF markers BNP/NT-proBNP insufficiently identify patients at risk for HFpEF death. Circulating methylated RASAL1, B9D1 and ATP2A2 most effectively identify patients at risk for HFpEF progression.
Keywords: liquid biopsy; HFpEF; heart failure with preserved ejection fraction; methylated DNA; biomarker; RASAL1; ATP2A2; B9D1

German

In dieser Arbeit werden drei mit dem Überleben von HFpEF-Patienten assoziierte Gene analysiert und deren Qualifikation als Biomarker für die klinische Progression von HFpEF herausgestellt. Zusätzlich konnte in dieser Kohorte deren Überlegenheit als Progressionsmarker über bisher etablierte Marker gezeigt werden
 

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