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dc.contributor.advisor Gruber, Oliver Prof. Dr.
dc.contributor.author Said, Jasmin
dc.date.accessioned 2020-05-26T09:14:43Z
dc.date.available 2020-06-06T22:50:03Z
dc.date.issued 2020-05-26
dc.identifier.uri http://hdl.handle.net/21.11130/00-1735-0000-0005-13AB-5
dc.language.iso deu de
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc 610 de
dc.title Decis State - Dysfunktionen neuronaler Mechanismen der Impulskontrolle bei Suchterkrankung –eine funktionell-kernspintomographische Untersuchung von Patienten mit langjähriger Alkoholabhängigkeit de
dc.type doctoralThesis de
dc.title.translated DECIS-State: Dysfunctional neural mechanisms of impulse control of addiction- A functional neuroimaging study of patients with longstanding alcohol addiction de
dc.contributor.referee Wilke, Melanie Prof. Dr.
dc.date.examination 2020-05-27
dc.description.abstracteng <p>The mesolimbic dopamine system plays a central role in the development of addiction. Some of its areas enable quick (impulsive) desires for preferred or conditioned stimuli. On the other hand, pre-frontal areas, which are disturbed in addictive patients, suppress impulsive behavior in favor of a long-term goal.</p> <p> A functional magnetic resonance imaging with a DRD-Paradigm was used to investigate potential dysfunctions of neurofunctional systems of impulse control in patients with longstanding alcohol dependence. </p><p> 17 patients and 15 controls were included in the clinical prospective study. </p><p> As expected, the abstinent alcoholics activated the areas of the mesolimbic dopamine system during presentation of alcoholic stimuli. In the Desire context, however, the patients showed a reduced activation of these areas. Together, these findings point to a higher salience of alcohol-associated stimuli. Moreover, it also took the patients longer to refuse alcoholic stimuli. Finally, in Reason-context the abstinent alcoholics showed a top-down suppression effect to alcoholic stimuli in favor of a long-term goal. We interpret this finding as a successful therapeutic effect after inpatient treatment. </p> de
dc.subject.eng Impulse control de
dc.identifier.urn urn:nbn:de:gbv:7-21.11130/00-1735-0000-0005-13AB-5-8
dc.affiliation.institute Medizinische Fakultät de
dc.subject.gokfull Psychiatrie (PPN619876344) de
dc.description.embargoed 2020-06-06
dc.identifier.ppn 1698857934

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