Zellexperimentell vergleichende Untersuchung zum Androgenrezeptor beim kastrationsresistenten Prostatakarzinom

Meyer-Wilmes, Kerstin

dc.contributor.advisor	Trojan, Lutz Prof. Dr.
dc.contributor.author	Meyer-Wilmes, Kerstin
dc.date.accessioned	2020-06-18T17:19:31Z
dc.date.available	2020-07-07T22:50:02Z
dc.date.issued	2020-06-18
dc.identifier.uri	http://hdl.handle.net/21.11130/00-1735-0000-0005-13E0-8
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-8021
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	610	de
dc.title	Zellexperimentell vergleichende Untersuchung zum Androgenrezeptor beim kastrationsresistenten Prostatakarzinom	de
dc.type	doctoralThesis	de
dc.title.translated	comparative studies of the role of androgen receptor in castration-resistant prostate cancer	de
dc.contributor.referee	Emons, Günter Prof. Dr.
dc.date.examination	2020-06-30
dc.description.abstracteng	The androgen receptor plays an important role in the progression of prostate cancer to castration-resistant prostate cancer. In this stage of the disease the standard treatment of androgen deprivation therapy does not work anymore. So in this study we try to reveal how the androgen receptor could be affected by the influence of histone deacetylase inhibitor valproate in the VCaP cells. Androgen receptor RNA and androgen regulated genes were measured and compared to the results of stimulation with the antiandrogen bicalutamide. The aim is to reduce the androgen driven effects in the cancer cell or to even decrease the level of androgen receptors. With small interfering RNA it is possible to silence the protein of the androgen receptor in vitro. We did this also and could see that an effective down-regulation of the androgen receptor is only shown in the siRNA experiment. But with valproate some really interesting androgen inhibiting and antitumoral effects were exposed.	de
dc.contributor.coReferee	Oppermann, Martin Prof. Dr.
dc.subject.ger	kastrationsresistentes Prostatakarzinom	de
dc.subject.ger	Valproat	de
dc.subject.ger	siRNA	de
dc.subject.ger	Androgenrezeptor	de
dc.subject.eng	castration resistant prostate cancer	de
dc.subject.eng	androgen receptor	de
dc.subject.eng	siRNA	de
dc.subject.eng	valproate	de
dc.identifier.urn	urn:nbn:de:gbv:7-21.11130/00-1735-0000-0005-13E0-8-2
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Medizin (PPN619874732)	de
dc.subject.gokfull	Urologie / Andrologie - Allgemein- und Gesamtdarstellungen (PPN619876131)	de
dc.description.embargoed	2020-07-07
dc.identifier.ppn	1701099152
dc.creator.birthname	Mösinger

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Human- und Zahnmedizin [2872]

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