Frakturrisikoevaluation mithilfe verschiedener nationaler und internationaler Risikoscores bei Männern
National and international osteoporosis fracture evaluation in men
von Judith Charlotte Witzel
Datum der mündl. Prüfung:2020-08-26
Erschienen:2020-08-03
Betreuer:Prof. Dr. Heide Siggelkow
Gutachter:PD Dr. Lukas Weiser
Gutachter:Prof. Dr. Margarete Schön
Dateien
Name:Promotionsarbeit Judith Charlotte Witzel ohn...pdf
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Zusammenfassung
Englisch
Different national and international scores are in use to evaluate the osteoporotic fracture probability in men. The DVO-Score is mainly established in Germany and calculates the 10-year-fracture probability, whereas the FRAX-Score is adopted worldwide. However, also in Germany the FRAX-Score is partly in use. FRAX calculates a 10-year-fracture-probability for four subscores (major osteoporotic fracture (MOF) and hip fracture (HF) with or without including osteodensitometry (OD)). We used established fracture probability scores (DVO, FRAX-Score with OD) and not established ("FRAX+", C. Glüer) scores to calculate the 10-year-fracture probability. Patient files were analyzed for DVO-based 10-year fracture probabilities and for data for the calculation of FRAX-Score for MOF and HF including OD. We used a therapeutic threshold of >30% for the DVO-Score and published thresholds ≥ 20% for MOF and ≥ 3% for HF for the FRAX-Score with OD. 10-year fracture probability was calculated for all 130 patients with OD. Conclusively the scores identify different male patients with indication for therapy, in our male patients the difference predominantly dependent on the RF age and BMD. We suggest careful consideration of the appropriate score in the daily care, especially in young male patients.
Keywords: osteoporosis; DXA; FRAX; DVO; bone minderal densitiy; secondary osteoporosis