Die Rolle der endothelialen Progenitorzellen und Gefäßsteifigkeit bei Patienten mit Psoriasis-Arthritis

Early endothelial progenitor cells and vascular stiffness in psoriasis and psoriatic arthritis

by Natalina Rosekie Sugiarto
Doctoral thesis
Date of Examination:2020-10-07
Date of issue:2020-09-03
Advisor:PD Dr. Susann Patschan
Referee:PD Dr. Susann Patschan
Referee:Prof. Dr. Rotraut Mößner
Persistent Address: http://dx.doi.org/10.53846/goediss-8183

 

 

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Abstract

English

Background: Both psoriasis (Ps) and psoriasis arthritis (PsA) have been associated with increased cardiovascular risk. Also, both are characterized by increased neovascularization. Endothelial progenitor cells (EPCs) have been implicated in promoting vascular repair in ischemic diseases. The aim of the study was to correlate the EPC system with CV risk factors and with parameters of vascular stiffness in Ps and PsA. Methods: Twenty-six healthy subjects, 30 patients with Ps, and 31 patients PsA were included in the study. eEPC regeneration was evaluated by a colony-forming assay, circulating eEPCs were measured by cytometric analysis. For vascular analysis, all subjects underwent quantification of pulse wave velocity (PWV) and augmentation index (AIX). Results: Patients were categorized upon the duration of disease, severity of skin involvement (PASI-Ps), individual pain as reflected by the VAS (PsA), CRP values, and history of treatment with one or more biologicals. Regarding the eEPC system, no significant differences were observed between the respective categories. Correlation analyses between parameters of vascular stiffness (PWV and AIX) and patterns of colony formation/circulating eEPCs did not show any correlation at all. Conclusion: Parameters of vascular stiffness are not significantly deteriorated in Ps/PsA. Thus, pulse wave analysis may not be suitable for CVR assessment in certain autoimmune-mediated diseases. Regenerative activity of the eEPC system/circulating eEPC numbers are not altered in Ps/PsA. One may conclude that malfunctions of the eEPC are not substantially involved in perpetuating the micro-/macrovascular alterations in Ps/PsA.
Keywords: eEPCs; Ps; PsA; CVR; Pulse wave velocity
 
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